Association of Serum 25-Hydroxyvitamin D Concentrations With Glucose Profiles in Male Collegiate Football Athletes
Association of Serum 25-Hydroxyvitamin D Concentrations With Glucose Profiles in Male Collegiate Football Athletes
复制标题
男性大学橄榄球运动员血清 25-羟基维生素 D 浓度与血糖状况的关联
DOI：
10.1123/ijsnem.2018-0225
复制
发表时间：
2019
影响因子：
2.5
通讯作者：
Higuchi Mitsuru
中科院分区：
文献类型：
--
作者：
Sun Xiaomin;Cao Zhen Bo;Tanisawa Kumpei;Oshima Satomi;Higuchi Mitsuru
低血清 25-羟基维生素 D [25(OH)D] 浓度与成人胰岛素抵抗和 2 型糖尿病的高风险相关。然而，尚不清楚美国大学橄榄球和橄榄球运动员是否属于这种情况。本研究调查了男性大学橄榄球运动员血清 25(OH)D 浓度与血糖曲线之间的关联。招募了 34 名年龄 21 岁的大学运动员（13 名美式橄榄球运动员和 21 名橄榄球运动员）。分别通过双能X射线吸收仪和磁共振成像测量他们的体脂百分比和内脏脂肪面积。参与者完成了口服葡萄糖耐量测试（75 克葡萄糖），并在 0、30、60、90 和 120 分钟时间点采集静脉血样本，以确定血浆葡萄糖和血清胰岛素浓度。还测量了空腹血清 25(OH)D 浓度。维生素 D 缺乏和不足的患病率分别为 17.6% 和 58.8%。血清 25(OH)D 浓度与葡萄糖曲线下面积 (iAUC) 增量呈负相关 (r= −.429,p= .011)，并且与松田指数显着相关 (r= −.303,p= .082)。血清 25(OH)D 浓度与其他葡萄糖谱之间没有观察到任何关系。以葡萄糖 iAUC 浓度为因变量的多元逐步回归分析表明，血清 25(OH)D 浓度（而非体脂指标）与葡萄糖 iAUC 独立相关（β = −0.390，p= .025）。血清 25(OH)D 浓度只是男性大学橄榄球运动员葡萄糖 iAUC 的独立预测因子，表明增加 25(OH)D 浓度有助于维持葡萄糖稳态。
Low serum 25-hydroxyvitamin D [25(OH)D] concentrations are associated with a high risk of insulin resistance and Type 2 diabetes mellitus in adults. However, it is unknown whether this is the case for American collegiate football and rugby football athletes. This study investigated the associations between serum 25(OH)D concentrations and glucose profiles in male collegiate football athletes. Thirty-four collegiate athletes (13 American football players and 21 rugby football players) aged 21 years were recruited. Their body fat percent and visceral fat area were measured by dual-energy X-ray absorptiometry and magnetic resonance imaging, respectively. The participants completed an oral glucose tolerance test (75 g glucose) with venous blood samples obtained at time points 0, 30, 60, 90, and 120 min for the determination of plasma glucose and serum insulin concentrations. Fasting serum 25(OH)D concentrations were also measured. The prevalence of vitamin D deficiency and insufficiency was 17.6% and 58.8%, respectively. The serum 25(OH)D concentrations were negatively associated with the increments in the areas under the curve (iAUC) for glucose (r= −.429,p= .011) and were borderline significantly correlated with the Matsuda index (r= −.303,p= .082). No relationships were observed between the serum 25(OH)D concentrations and other glucose profiles. Multiple stepwise regression analysis of glucose iAUC concentrations as the dependent variable indicated that the serum 25(OH)D concentrations, but not body fat indicators, were independently associated with glucose iAUC (β = −0.390,p= .025). The serum 25(OH)D concentrations were only an independent predictor for glucose iAUC in male collegiate football athletes, suggesting that increased 25(OH)D concentrations would be helpful for maintaining glucose homeostasis.