PROSTAGLANDINS - MEMBERS OF A NEW HORMONAL SYSTEM
PROSTAGLANDINS - MEMBERS OF A NEW HORMONAL SYSTEM
复制标题
DOI：
10.1126/science.157.3787.382
复制
发表时间：
1967-01-01
期刊：
影响因子：
56.9
通讯作者：
BERGSTROM, S
中科院分区：
文献类型：
--
作者：
BERGSTROM, S
1930年，两位纽约妇科医生Kurzrok和Lieb(1)报道，当注入新鲜的人类精液时，人类子宫会产生强烈收缩或松弛的反应。我们现在知道，这些影响是由于存在于精浆中的前列腺素，但直到几年后，人们才清楚地认识到，这种影响是由于这些当时未知的化合物的存在。英国的Goldblatt(2)和瑞典的von Euler(3)分别独立发现并研究了精浆中刺激平滑肌的强烈活性。冯·欧拉对几个物种的精浆进行了研究，他发现只有猴子、绵羊和山羊的精液以及雄性绵羊的水疱腺提取物中有类似的效果。他制备了这些腺体的脂质提取物，发现其活性与含有脂溶性酸的部分有关。他将活性因子命名为前列腺素，并对这些提取物的生理和药理作用进行了广泛的研究(3)。
In 1930 two New York gynecologists, Kurzrok and Lieb (1), reported that the human uterus could reactwith either strong contractions or relaxation on instillation of fresh human semen. We now know that these effects were due to the prostaglandins present in the seminal plasma, but not until a few years later was it clearly recognized that the effect was due to the presence of these then-unknown compounds. Goldblatt (2) in England and von Euler (3) in Sweden independently discovered and studied the strong ac-tivity in seminal plasma that stimu-lates smooth muscle. The seminal plasma of several species was investigated by von Euler, who found similar effects in the seminal fluid of only monkey, sheep, and goat and-in ex-tracts of vesicular glands of male sheep. He prepared lipid extracts of these glands and found the activity to be associated with the fraction containing the lipid-soluble acids. He named the active factor prostaglandin and made extensive studies of the physiologic and pharmacologic effects of these extracts (3).