New acylated iridoid glucosides from Vitex altissima
New acylated iridoid glucosides from Vitex altissima
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DOI：
10.1021/np040117r
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发表时间：
2004-12-01
影响因子：
5.1
通讯作者：
Venugopal, RT
中科院分区：
文献类型：
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作者：
Sridhar, C;Subbaraju, GV;Venugopal, RT
六种新的环烯醚萜苷类化合物，6 ′-O-反式-阿魏酰Negundoside（1），6 ′-O-反式-咖啡酰Negundoside（2），2 ′-O-对羟基苯甲酰基-6 ′-O-反式-咖啡酰栀子苷（3），2 ′-O-对羟基苯甲酰基-6 ′-O-反式-咖啡酰-8-表原酸（4），2 ′-O-对羟基苯甲酰基栀子苷（5）和2 ′-O-对羟基苯甲酰基-8-表原酸（6），沿着两种已知的环烯醚萜类化合物，从高蔓荆子（Vitex altissima）叶的乙酸乙酯提取物中分离得到了agnuside和negundoside。根据光谱数据的解释，确定了这些化合物的结构。这些分离物没有表现出显着的5-脂氧合酶的酶抑制活性，但化合物2-4显示出有效的抗氧化活性的超氧化物（NBT核黄素光还原）自由基清除和DPPH自由基清除方法。在大鼠爪水肿测定中评价化合物1、2和黄荆苷。
Six new iridoid glucosides, 6'-O-trans-feruloylnegundoside (1), 6'-O-trans-caffeoylnegundoside (2), 2'-O-p-hydroxybenzoyl-6'-O-trans-caffeoylgardoside (3), 2'-O-p-hydroxybenzoyl-6'-O-trans-caffeoyl-8-epiloganic acid (4), 2'-O-p-hydroxybenzoyl gardoside (5), and 2'-O-p-hydroxybenzoyl-8-epiloganic acid (6), along with two known iridoids, agnuside and negundoside, have been isolated from the ethyl acetate extractive of the leaves of Vitex altissima. The structures of these compounds were elucidated on the basis of spectral data interpretation. These isolates did not exhibit significant 5-lipoxygenase enzyme inhibitory activity, but compounds 2-4 showed potent antioxidant activity by both the superoxide (NBT riboflavin photoreduction) free-radical-scavenging and DPPH-radical-scavenging methods. Compounds 1, 2, and negundoside were evaluated in a rat paw edema assay.