The Pavlovian power of palatable food: lessons for weight-loss adherence from a new rodent model of cue-induced overeating
The Pavlovian power of palatable food: lessons for weight-loss adherence from a new rodent model of cue-induced overeating
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DOI：
10.1038/ijo.2009.57
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发表时间：
2009-06-01
影响因子：
4.9
通讯作者：
Murdaugh, D. L.
中科院分区：
文献类型：
--
作者：
Boggiano, M. M.;Dorsey, J. R.;Murdaugh, D. L.
目的：暴饮暴食是肥胖治疗中的一个顽症。我们测试的假设，上下文线索周围可口的食物（PF）的摄入量有权力破坏热量调节，甚至更少的PF. Context线索是非食物的线索，是在PF是习惯eat.Design的环境中：大鼠条件相关联的摄入奥利奥饼干作为PF的笼子与不同的上下文线索，在笼子里，他们只被给予食物的线索。PF自然刺激更多的热量摄入。然后在PF笼中测试大鼠，仅提供食物，以确定PF配对的线索，单独的，是否可以引起过度进食的平原chow.Subjects：非食物剥夺雌性Sprague-Dawley rates.Measurements：摄入平原chow-paired线索下PF配对的线索与chow-paired线索进行了比较。这一点也在一些测试中得到了测量，这些测试包括一点PF作为启动刺激。我们还控制了暴食倾向与暴食抵抗状态的任何影响，以预测提示暴饮暴食。结果：大鼠消耗显着更多的食物时，暴露于上下文线索配对PF早于与食物（P < 0.01）。这种效果发生在各种线索（例如，不同类型的床上用品或墙纸）。这种效应通过一小块PF（P < 0.001）引发而得到加强，并且不受PF上狂欢倾向的基线差异的影响。结论：与PF摄入相关的上下文线索可以驱动即使是较低的PF也过度进食，并且消除大鼠补偿PF引发剂的卡路里的能力。正如药物相关的背景线索可以恢复药物成瘾复发，PF配对线索可能引发与体重反弹和肥胖有关的暴饮暴食复发。这个模型应该有助于识别破坏坚持健康的减少热量方案的反射样生物学，并呼吁更多地关注暴饮暴食和肥胖治疗中的线索因素。International Journal of Obesity（2009）33，693-701; doi：10.1038/ijo.2009.57; 2009年4月7日在线发表
Objective: Relapsing to overeating is a stubborn problem in obesity treatment. We tested the hypothesis that context cues surrounding palatable food (PF) intake have the power to disrupt caloric regulation even of less PF. Context cues are non-food cues that are in the environment where PF is habitually eaten.Design: Rats were conditioned to associate intake of Oreo cookies as the PF to cages with distinct context cues that differed from cues in cages where they were only given chow. PF naturally stimulated greater caloric intake. The rats were then tested in the PF cage with only chow available to determine whether the PF-paired cues, alone, could elicit overeating of plain chow.Subjects: Non-food-deprived female Sprague-Dawley rats.Measurements: Intake of plain chow under PF-paired cues vs chow-paired cues was compared. This was also measured in tests that included a morsel of PF as a priming stimulus. We also controlled for any effect of binge-prone vs binge-resistant status to predict cued-overeating.Results: Rats consumed significantly more chow when exposed to context cues paired earlier with PF than with chow (P < 0.01). This effect occurred using various cues (for example, different types of bedding or wallpaper). The effect was strengthened by priming with a morsel of PF (P < 0.001) and was unaffected by baseline differences in propensity to binge on PF.Conclusion: Context-cues associated with PF intake can drive overeating even of a less PF and abolish the ability of rats to compensate for the calories of a PF primer. Just as drug-associated context cues can reinstate drug-addiction relapse, PF-paired cues may trigger overeating relapses linked to weight regain and obesity. This model should help identify the reflex-like biology that sabotages attempts to adhere to healthy reduced calorie regimens and call greater attention to the cue-factor in the treatment of binge eating and obesity. International Journal of Obesity (2009) 33, 693-701; doi: 10.1038/ijo.2009.57; published online 7 April 2009