Effects of Meal Timing on Postprandial Glucose Metabolism and Blood Metabolites in Healthy Adults
Effects of Meal Timing on Postprandial Glucose Metabolism and Blood Metabolites in Healthy Adults
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DOI：
10.3390/nu10111763
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发表时间：
2018-11-01
期刊：
影响因子：
5.9
通讯作者：
Shibata, Shigenobu
中科院分区：
文献类型：
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作者：
Takahashi, Masaki;Ozaki, Mamiho;Shibata, Shigenobu
我们研究了进餐时间对餐后葡萄糖代谢的影响，包括健康成人的肠促胰岛素反应和代谢产物。19名健康的年轻男性完成了两项试验，包括在空腹状态下以及在餐后30、60和120分钟以随机顺序采集血液：（1）早晨（类似于0900 h）和（2）晚上（类似于1700 h）。使用毛细管电泳-质谱法分析了8名参与者的血液代谢组。晚上试验中120分钟的餐后葡萄糖浓度（p = 0.030）和60分钟的葡萄糖依赖性促胰岛素多肽浓度（p = 0.005）高于早晨试验。5种糖酵解、三羧酸循环和核苷酸相关代谢物以及18种氨基酸相关代谢物的曲线下面积增量值在早晨试验中高于晚上试验（p < 0.05）。偏最小二乘分析表明，总代谢变化在上午较高。我们的研究表明，在健康成人中，晚餐会加剧餐后高血糖状态。此外，本研究还揭示了早餐和晚餐之间内分泌和血液代谢产物的差异，表明总代谢反应在早晨往往更高。
We examined the effects of meal timing on postprandial glucose metabolism, including the incretin response and metabolites in healthy adults. Nineteen healthy young men completed two trials involving blood collection in a fasting state and at 30, 60 and 120 min after meal provision in a random order: (1) morning (similar to 0900 h) and (2) evening (similar to 1700 h). The blood metabolome of eight participants was analyzed using capillary electrophoresis-mass spectrometry. Postprandial glucose concentrations at 120 min (p = 0.030) and glucose-dependent insulinotropic polypeptide concentrations (p = 0.005) at 60 min in the evening trials were higher than those in the morning trials. The incremental area under the curve values of five glycolysis, tricarboxylic acid cycle and nucleotide-related metabolites and 18 amino acid-related metabolites were higher in the morning trials than those in the evening trials (p < 0.05). Partial least-squares analysis revealed that the total metabolic change was higher in the morning. Our study demonstrates that a meal in the evening exacerbates the state of postprandial hyperglycemia in healthy adults. In addition, this study provides insight into the difference of incretion and blood metabolites between breakfast and dinner, indicating that the total metabolic responses tends to be higher in the morning.