The pseudoGTPase group of pseudoenzymes.
The pseudoGTPase group of pseudoenzymes.
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DOI：
10.1111/febs.15554
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发表时间：
2020-10
期刊：
影响因子：
--
通讯作者：
Boggon TJ
中科院分区：
文献类型：
--
作者：
Stiegler AL;Boggon TJ
假酶作为信号转导的重要介质和调节剂而出现。这些蛋白质保持酶折叠和拓扑结构，但在酶活性所需的保守基序中被破坏。在假酶中，非典型GTP酶的假GTP酶组最近已经扩展，并且包括Rnd和RGK组、RhoH和RhoBTB蛋白、Miro和centaurin-γ组、CENP-M、动力蛋白LIC、EhRabX 3、LRRK 2和p190 RhoGAP蛋白。与pseudoGTP酶相关的广泛的细胞功能包括细胞迁移和粘附、膜运输和货物运输、有丝分裂、线粒体活性、转录控制和自噬，使该组处于不断扩大的信号传导途径组合中。在这篇综述中，我们研究如何pseudoGTPases不同于典型的GTPases，并考虑其在信号转导机制和功能的作用。我们回顾了pseudoGTPases之间的氨基酸差异，并讨论了这些蛋白质如何根据其结合核苷酸的能力和酶活性进行分类。我们讨论了典型的GTP酶的氨基酸分歧的分子和结构的后果，并使用比较研究的假激酶来说明分类。伪GTP酶正在迅速成为公认的重要机械组件在一系列的细胞作用，我们提供了一个简明的讨论，目前确定的成员，这组。
Pseudoenzymes are emerging as significant mediators and regulators of signal transduction. These proteins maintain enzyme folds and topologies, but are disrupted in the conserved motifs required for enzymatic activity. Among the pseudoenzymes, the pseudoGTPase group of atypical GTPases has recently expanded and includes the Rnd and RGK groups, RhoH and the RhoBTB proteins, Miro and centaurin-γ groups, CENP-M, dynein LIC, EhRabX3, LRRK2 and the p190RhoGAP proteins. The wide range of cellular functions associated with pseudoGTPases include cell migration and adhesion, membrane trafficking and cargo transport, mitosis, mitochondrial activity, transcriptional control and autophagy, placing the group in an expanding portfolio of signaling pathways. In this review we examine how the pseudoGTPases differ from canonical GTPases and consider their mechanistic and functional roles in signal transduction. We review the amino acid differences between the pseudoGTPases and discuss how these proteins can be classified based on their ability to bind nucleotide and their enzymatic activity. We discuss the molecular and structural consequences of amino acid divergence from canonical GTPases and use comparison with the well-studied pseudokinases to illustrate the classifications. PseudoGTPases are fast becoming recognized as important mechanistic components in a range of cellular roles and we provide a concise discussion of the currently identified members of this group.
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影响因子：
3.5
作者：
Biosa, Alice;Trancikova, Alzbeta;Moore, Darren J.
通讯作者：
Moore, Darren J.
影响因子：
3.5
作者：
Blanca Ramírez M;Lara Ordóñez AJ;Fdez E;Madero-Pérez J;Gonnelli A;Drouyer M;Chartier-Harlin MC;Taymans JM;Bubacco L;Greggio E;Hilfiker S
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Hilfiker S
伪GTPASE CENP-M驱动人类动物组件。
影响因子：
7.7
作者：
Basilico F;Maffini S;Weir JR;Prumbaum D;Rojas AM;Zimniak T;De Antoni A;Jeganathan S;Voss B;van Gerwen S;Krenn V;Massimiliano L;Valencia A;Vetter IR;Herzog F;Raunser S;Pasqualato S;Musacchio A
通讯作者：
Musacchio A
影响因子：
7.8
作者：
CHANG, JH;GILL, S;SETTLEMAN, J;PARSONS, SJ
通讯作者：
PARSONS, SJ
影响因子：
3.3
作者：
Arthur, WT;Burridge, K
通讯作者：
Burridge, K