Preparation of Spherical and Porous Chitosan Particles by Suspension Evaporation with O/W/O Multiple Emulsions
Preparation of Spherical and Porous Chitosan Particles by Suspension Evaporation with O/W/O Multiple Emulsions
复制标题
O/W/O多重乳液悬浮蒸发制备球形多孔壳聚糖颗粒
DOI：
10.1295/polymj.31.319
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发表时间：
1999
期刊：
影响因子：
2.8
通讯作者：
C. Hirayama
中科院分区：
文献类型：
--
作者：
T. Adachi;J. Ida;M. Wakita;M. Hashimoto;H. Ihara;C. Hirayama
采用常规悬浮蒸发改性法制备壳聚糖多孔球形颗粒。壳聚糖水溶液以十氢萘为悬浮介质，以非离子表面活性剂为乳化剂进行分散。制备了由壳聚糖水颗粒（含十氢萘）组成的O/w/ O复合乳液，并将其分散在十氢萘中。壳聚糖为不溶性球形颗粒，通过加热逐步脱水沉淀。颗粒孔隙度与微乳液的形成、乳化剂的浊点和所用酸的化学结构有关。
Porous spherical particles of chitosan were prepared by conventional suspension evaporation with modification. Aqueous chitosan solution was dispersed in decahydronaphthalene as the suspension medium with a nonionic surfactant as the emulsifier. O/w/o multiple emulsions consisting of aqueous chitosan particles containing decahydronaphthalene and dispersed in decahydronaphthalene were obtained. Chitosan precipitated as insoluble spherical particles by the gradual removal of water with heating. Particle porosity was related to microemulsions formation, the cloud point of the emulsifier and chemical structure of the acid used.