Particulate matter promotes hyperpigmentation via AhR/MAPK signaling activation and by increasing a-MSH paracrine levels in keratinocytes
Particulate matter promotes hyperpigmentation via AhR/MAPK signaling activation and by increasing a-MSH paracrine levels in keratinocytes
复制标题
颗粒物质通过 AhR/MAPK 信号激活和增加角质形成细胞中的 a-MSH 旁分泌水平促进色素沉着过度
DOI：
10.1016/j.envpol.2021.116850
复制
发表时间：
2021-03-09
影响因子：
8.9
通讯作者：
Xiao, Rong
中科院分区：
文献类型：
--
作者：
Shi, Yaqian;Zeng, Zhuotong;Xiao, Rong
环境空气中空气动力学当量直径小于等于2.5 mm的颗粒物（PM2.5）已成为全球性的公共和环境问题，控制空气中PM2.5浓度是一个亟待解决的问题。PM2.5很容易穿透皮肤，激活皮肤的炎症反应，破坏皮肤屏障功能，导致皮肤老化。色素沉着过度是皮肤老化的主要表现，对全球生活质量有相当大的影响。到目前为止，还没有关于PM2.5对色素沉着的影响的研究。在这里，我们说明，PM2.5可以诱导黑素生成在体内和体外通过调节TYR，TYRP 1，TYRP 2，和MITF表达通过AhR/ MAPK信号激活。此外，PM2.5增加a-MSH旁分泌水平，这反过来促进色素沉着过度。我们的研究结果提供了对PM2.5如何破坏皮肤稳态和功能的更深入了解。用AhR拮抗剂治疗可能是PM2.5诱导的色素沉着过度的潜在治疗策略。(c)2021爱思唯尔有限公司版权所有。
Particulate matter with an aerodynamic equivalent diameter of 2.5 mm or less in ambient air (PM2.5) has become a global public and environmental problem, and the control of the PM2.5 concentration in air is an urgent problem. PM2.5 can easily penetrate the skin, activating the inflammatory response in skin, unbalancing the skin barrier function, and inducing skin aging. Hyperpigmentation is the main manifestation of skin aging and has a considerable impact on quality of life worldwide. To date, no research on the influence of PM2.5 on hyperpigmentation has been conducted. Here, we illustrate that PM2.5 can induce melanogenesis in vivo and in vitro by regulating TYR, TYRP1, TYRP2, and MITF expression via AhR/ MAPK signaling activation. Furthermore, PM2.5 increased a-MSH paracrine levels, which in turn promote hyperpigmentation. Our results provide a deeper understanding of how PM2.5 disrupts skin homeostasis and function. Treatment with AhR antagonists may be a potential therapeutic strategy for hyperpigmentation induced by PM2.5.(c) 2021 Elsevier Ltd. All rights reserved.