Excessive Postural Sway and the Risk of Falls at Different Stages of Parkinson's Disease
Excessive Postural Sway and the Risk of Falls at Different Stages of Parkinson's Disease
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DOI：
10.1002/mds.22358
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发表时间：
2009-02-15
影响因子：
8.6
通讯作者：
Bronte-Stewart, Helen
中科院分区：
文献类型：
--
作者：
Frenklach, Arma;Louie, Stephanie;Bronte-Stewart, Helen
过度的体位摇摆可能导致帕金森病（PD）患者跌倒。本研究采用动态体位测量的感觉组织测试（SOT），在静态（静止平台）和动态（摇摆参考平台）条件下测量102例PD患者在正常、无和不适当的视觉反馈下的姿势摇摆。25名健康受试者作为年龄匹配的对照。18名非常早期的PD患者从未使用过多巴胺能药物。在所有情况下，这些受试者的体位摇摆都是正常的，但在症状更严重的受试者中，体位摇摆是异常的（UPDRS III bbb20, P < 0.01）。除了静止不动和闭眼外，在所有情况下，体位摇摆随疾病严重程度的增加而增加(P < 0.0001)。我们开发了SOT跌倒严重程度量表（SOTFSS）从次数的姿势摇摆是如此之大，以至于。受试者必须迈出这一步（登记为“跌倒”），并表明跌倒主要发生在动态条件下，并且与疾病严重程度相关（P < 0.0001）。在动态条件下，SOTFSS与UPDRS III的后退得分（N = 102, P < 0.0001）和受试者自报告的UPDRS II跌倒频率（N = 62, SOT5: P = 0.0419, SOT6: P 0.0034）相关。(C) 2008运动障碍学会
Excessive Postural sway may result in falls in Parkinson's disease (PD). We measured postural sway using the sensory organization test (SOT) of dynamic posturography in static (platform still) and dynamic (sway referenced platform) conditions with normal, no and inappropriate visual feedback in 102 subjects with PD, off medication. Twenty-five healthy subjects Were used as age-matched controls. Eighteen very early stage PD subjects had never used dopaminergic medication. Postural sway was normal in those subjects in all conditions, but was abnormal in subjects with more advanced symptoms (UPDRS III > 20, P < 0.01). Postural sway increased with disease severity in all conditions except static, eyes closed (P < 0.0001). We developed the SOT Fall Severity Scale (SOTFSS) from the number of times postural sway was so large that. the subject had to take it step (registered as a "fall") and showed that falls mainly occurred in dynamic conditions, and were correlated with disease severity (P < 0.0001). In dynamic conditions the SOTFSS was correlated with the retropulsion score from the UPDRS III (N = 102, P < 0.0001) and with the subjects' self-reported fall frequency from the UPDRS II (N = 62, SOT5: P = 0.0419, SOT6: P 0.0034). (C) 2008 Movement Disorder Society