Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial.
Apolipoprotein L1 gene variants associate with prevalent kidney but not prevalent cardiovascular disease in the Systolic Blood Pressure Intervention Trial.
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DOI：
10.1038/ki.2014.254
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发表时间：
2015-01
影响因子：
19.6
通讯作者：
中科院分区：
文献类型：
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载脂蛋白L1基因（APOL 1）G1和G2编码变体与非裔美国人的慢性肾脏病（CKD）密切相关。在这里，APOL 1与基线估计肾小球滤过率（eGFR），尿白蛋白：肌酐比值（UACR）和流行心血管疾病（CVD）的相关性在2,571名来自收缩压干预试验（SPRINT）的非洲裔美国人中进行了测试，该试验评估了收缩压降低对肾脏和CVD结局的影响。校正潜在重要混杂因素的Logistic回归模型检测了APOL 1风险变体与基线临床CVD（心肌梗死、冠状动脉或颈动脉血运重建）和CKD（eGFR低于60 ml/min/1.73m2和/或UACR超过30 mg/g）之间的相关性。非裔美国人SPRINT参与者中45.3%为女性，平均（中位）年龄为64.3（63）岁，平均动脉压100.7（100）mmHg，eGFR 76.3（77.1）ml/min/1.73m2，UACR 49.9（9.2）mg/g，8.2%患有临床CVD。APOL 1（隐性遗传）与CKD呈正相关（比值比1.37，95%置信区间1.08-1.73），log UACR估计斜率[β] 0.33），与eGFR呈负相关（β −3.58），均具有显著性。APOL 1风险变异与CVD患病率无显著相关性（1.02，0.82-1.27）。因此，SPRINT数据显示APOL 1风险变异与轻度CKD相关，但与UACR低于1000 mg/g的非裔美国人中的普遍CVD无关。
Apolipoprotein L1 gene (APOL1) G1 and G2 coding variants are strongly associated with chronic kidney disease (CKD) in African Americans. Here APOL1 association was tested with baseline estimated glomerular filtration rate (eGFR), urine albumin:creatinine ratio (UACR), and prevalent cardiovascular disease (CVD) in 2,571 African Americans from the Systolic Blood Pressure Intervention Trial (SPRINT), a trial assessing effects of systolic blood pressure reduction on renal and CVD outcomes. Logistic regression models that adjusted for potentially important confounders tested for association between APOL1 risk variants and baseline clinical CVD (myocardial infarction, coronary or carotid artery revascularization) and CKD (eGFR under 60 ml/min/1.73m2 and/or UACR over 30 mg/g). African American SPRINT participants were 45.3% female with mean (median) age of 64.3 (63) years, mean arterial pressure 100.7 (100) mmHg, eGFR 76.3 (77.1) ml/min/1.73m2, UACR 49.9 (9.2) mg/g, and 8.2% had clinical CVD. APOL1 (recessive inheritance) was positively associated with CKD (odds ratio 1.37, 95% confidence interval 1.08–1.73) and log UACR estimated slope [β] 0.33) and negatively associated with eGFR (β −3.58), all significant. APOL1 risk variants were not significantly associated with prevalent CVD (1.02, 0.82–1.27). Thus, SPRINT data show that APOL1 risk variants are associated with mild CKD but not prevalent CVD in African American with a UACR under 1000 mg/g.
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DOI：
10.1056/nejmoa0910975
发表时间：
2010-09-02
期刊：
The New England journal of medicine
影响因子：
--
作者：
Appel LJ;Wright JT Jr;Greene T;Agodoa LY;Astor BC;Bakris GL;Cleveland WH;Charleston J;Contreras G;Faulkner ML;Gabbai FB;Gassman JJ;Hebert LA;Jamerson KA;Kopple JD;Kusek JW;Lash JP;Lea JP;Lewis JB;Lipkowitz MS;Massry SG;Miller ER;Norris K;Phillips RA;Pogue VA;Randall OS;Rostand SG;Smogorzewski MJ;Toto RD;Wang X;AASK Collaborative Research Group
通讯作者：
AASK Collaborative Research Group
DOI：
10.1126/science.1193032
发表时间：
2010-08-13
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Genovese G;Friedman DJ;Ross MD;Lecordier L;Uzureau P;Freedman BI;Bowden DW;Langefeld CD;Oleksyk TK;Uscinski Knob AL;Bernhardy AJ;Hicks PJ;Nelson GW;Vanhollebeke B;Winkler CA;Kopp JB;Pays E;Pollak MR
通讯作者：
Pollak MR
影响因子：
13.6
作者：
Kopp, Jeffrey B.;Nelson, George W.;Winkler, Cheryl A.
通讯作者：
Winkler, Cheryl A.
影响因子：
13.6
作者：
Friedman, David J.;Kozlitina, Julia;Pollak, Martin R.
通讯作者：
Pollak, Martin R.
影响因子：
15.9
作者：
Friedman, David J.;Pollak, Martin R.
通讯作者：
Pollak, Martin R.