Heterogeneity of the Peripheral Circadian Systems in Drosophila melanogaster: A Review.
Heterogeneity of the Peripheral Circadian Systems in Drosophila melanogaster: A Review.
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DOI：
10.3389/fphys.2016.00008
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发表时间：
2016
影响因子：
4
通讯作者：
Tomioka K
中科院分区：
文献类型：
--
作者：
Ito C;Tomioka K
生物体的昼夜节律涉及新陈代谢、生理和行为的许多方面。在许多动物中，这些节律是由昼夜节律系统产生的，该系统由位于大脑的中央时钟和各种外周组织的外周时钟组成。不同组织和器官的外周时钟的振荡机制和夹带机制有所不同。中央时钟和外周时钟之间的关系也是组织依赖性的。在这里，我们回顾了果蝇果蝇外周生物钟的异质性及其对中央生物钟的依赖性，并讨论了它们在外周组织/器官生理学时间组织中的意义。
Circadian rhythms in organisms are involved in many aspects of metabolism, physiology, and behavior. In many animals, these rhythms are produced by the circadian system consisting of a central clock located in the brain and peripheral clocks in various peripheral tissues. The oscillatory machinery and entrainment mechanism of peripheral clocks vary between different tissues and organs. The relationship between the central and peripheral clocks is also tissue-dependent. Here we review the heterogeneous nature of peripheral circadian clocks in the fruit fly Drosophila melanogaster and their dependence on the central clock, and discuss their significance in the temporal organization of physiology in peripheral tissues/organs.