Airway responses of healthy farmers and nonfarmers to exposure in a swine confinement building
Airway responses of healthy farmers and nonfarmers to exposure in a swine confinement building
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DOI：
10.5271/sjweh.673
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发表时间：
2002-08-01
影响因子：
6.3
通讯作者：
Larsson, K
中科院分区：
文献类型：
--
作者：
Palmberg, L;Larssson, BM;Larsson, K
目的-本研究的目的是确定是否猪农民不断暴露于农业环境的反应不同，急性暴露比以前未暴露nonfarmers.Methods九个健康的nonfarmers，以前没有暴露于农业环境，和8个猪农民暴露在猪禁闭建设3个小时，而称重猪。在暴露前后进行肺功能测量、乙酰甲胆碱激发试验和鼻灌洗。在暴露日期间重复采集血样。结果两组暴露水平相同，暴露后鼻腔灌洗液和血液中细胞分类计数和细胞因子水平均显著高于对照组。支气管对乙酰甲胆碱的反应性增加了4.0的中位数（非农民中第25 - 75个单位为2.2-10.1）和0.7（农民中第25 - 75个单位为0.01-3.5）。白细胞介素-6的血清中位水平从3.8（25 - 75岁）增加到3.8（25 - 75岁）。
Objectives The objective of the study was to determine whether swine farmers continuously exposed to the farming environment react differently to acute exposure than previously unexposed nonfarmers.Methods Nine healthy nonfarmers, not previously exposed to a farming environment, and eight swine farmers were exposed in a swine confinement building for 3 hours while weighing pigs. Lung function measurements, methacholine challenge tests, and nasal lavages were performed before and after the exposure. Blood samples were drawn repeatedly during the exposure day. Differential cell counts and cytokine levels were analyzed in the nasal lavage fluid and blood.Results The exposure levels were the same in both groups. Bronchial responsiveness to methacholine increased by a median of 4.0 (25th-75th percentiles 2.2-10.1 among the nonfarmers) and 0.7 (25th-75th percentiles 0.01-3.5 among the farmers) doubled concentration steps. The median serum levels of interleukin-6 increased from 3.8 (25th-75th percentiles