Transmission and evolution of tick-borne viruses
Transmission and evolution of tick-borne viruses
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DOI：
10.1016/j.coviro.2016.08.005
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发表时间：
2016-12-01
影响因子：
5.9
通讯作者：
Armstrong, Philip M.
中科院分区：
文献类型：
--
作者：
Brackney, Doug E.;Armstrong, Philip M.
蜱传播多种病毒，例如蜱传脑炎病毒、波瓦桑病毒和克里米亚-刚果出血热病毒，这些病毒在世界许多地区重新出现。大多数蜱传病毒 (TBV) 都是 RNA 病毒，它们使用容易出错的聚合酶进行复制，并产生遗传多样性的病毒群体，从而促进其快速进化和适应新环境。本文回顾了蜱载体传播病毒的机制、自然界中传播的 TBV 的分子进化，以及宿主体内病毒多样性的形成过程，以更好地了解这些病毒如何成为公共卫生威胁。此外，还讨论了剩余的问题和未来的研究方向。
Ticks transmit a diverse array of viruses such as tick-borne encephalitis virus, Powassan virus, and Crimean-Congo hemorrhagic fever virus that are reemerging in many parts of the world. Most tick-borne viruses (TBVs) are RNA viruses that replicate using error-prone polymerases and produce genetically diverse viral populations that facilitate their rapid evolution and adaptation to novel environments. This article reviews the mechanisms of virus transmission by tick vectors, the molecular evolution of TBVs circulating in nature, and the processes shaping viral diversity within hosts to better understand how these viruses may become public health threats. In addition, remaining questions and future directions for research are discussed.