FOOD REWARD AND COCAINE INCREASE EXTRACELLULAR DOPAMINE IN THE NUCLEUS ACCUMBENS AS MEASURED BY MICRODIALYSIS
FOOD REWARD AND COCAINE INCREASE EXTRACELLULAR DOPAMINE IN THE NUCLEUS ACCUMBENS AS MEASURED BY MICRODIALYSIS
复制标题
DOI：
10.1016/0024-3205(88)90036-7
复制
发表时间：
1988-01-01
期刊：
影响因子：
6.1
通讯作者：
HOEBEL, BG
中科院分区：
文献类型：
--
作者：
HERNANDEZ, L;HOEBEL, BG
通过微透析法测量自由活动的大鼠的延髓核中的多巴胺，同时他们经历了奖励食物，脑刺激和药物。当动物按下杠杆获得食物奖励时，细胞外多巴胺增加了37%。电刺激下丘脑外侧的进食奖励（自我刺激）部位，在有或没有食物的情况下，也会引起多巴胺的类似增加。在大鼠将给自己注射安非他明的丘脑核部位，注射安非他明或可卡因使细胞外多巴胺增加了5倍。因此，安非他明和可卡因增加了行为强化系统中的多巴胺，而这个系统通常是由进食激活的。相反，通过进食释放多巴胺可能是食物成瘾的一个因素。
Dopamine was measured by microdialysis in the nucleus accumbens of freely moving rats while they experienced rewarding food, brain stimulation and drugs. Extracellular dopamine increased 37% when the animals pressed a lever for food reward. Electrical stimulation of a lateral hypothalamic feeding-reward (self-stimulation) site caused a similar increase in dopamine, with or without food. At the site in the nucleus accumbens where rats will administer amphetamine to themselves, injections of amphetamine or cocaine increased extracellular dopamine fivefold. Thus amphetamine and cocaine increase dopamine in a behavior reinforcement system which is normally activated by eating. Conversely, the release of dopamine by eating could be a factor in addiction to food.