Isolation, Chemical Identification and Pharmacological Evaluation of Eucryphin, Astilbin and Engelitin Obtained from the Bark of Hymenaea martiana
Isolation, Chemical Identification and Pharmacological Evaluation of Eucryphin, Astilbin and Engelitin Obtained from the Bark of Hymenaea martiana
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DOI：
10.3109/13880209309082916
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发表时间：
1993
期刊：
影响因子：
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通讯作者：
Eliane Carneiro;J. Calixto;F. Monache;R. Yunes
中科院分区：
文献类型：
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作者：
Eliane Carneiro;J. Calixto;F. Monache;R. Yunes
摘要本研究旨在分离，化学表征，并评价存在于从膜的树皮粗提取物的活性成分。鉴定了β-谷甾醇-3-O-糖苷和3种鼠李糖苷（eucryphin、engelitin和落新妇苷）。如前所述，从H.在离体大鼠子宫中，糖苷类真红细胞肽（29.5-236 μM）引起缓激肽（BK）浓度响应曲线的浓度依赖性位移。相比之下，落新妇苷（22-176 μM）和engeletin（21-92 μM）仅引起BK诱导收缩右侧的离散位移。乙酰化落新妇苷（18-72 μM）和Eucryphin（13-53 μM）引起BK浓度-反应曲线的平行和浓度依赖性位移，并与最大收缩的轻微抑制有关。然而，这些糖苷的拮抗作用被发现对BK是非选择性的，因为在相同的浓度下...
AbstractThis study was designed to isolate, chemically characterize, and pharmacologically evaluate the active principles present in a crude extract from the bark of Hymenaea martiana. β-Sitosterol-3-O-glycoside and three rhamnosides (eucryphin, engelitin and astilbin) were identified. As demonstrated previously with an alcohol extract from H. martiana, the glycoside eucryphin (29.5-236 μM) caused a concentration-dependent rightward displacement of the bradykinin (BK) concentration response curve in the isolated rat uterus. In contrast, astilbin (22-176 μM) and engeletin (21-92 μM) caused only a discrete displacement to the right of BK-induced contractions. Acetylated astilbin (18-72 μM) and eucryphin (13-53 μM) caused a parallel and concentration-dependent displacement to the right of BK concentration-response curves associated with slight depression of the maximal contraction. However, the antagonistic actions of these glycosides were found to be non-selective against BK, since at the same concentration...