Universal physical responses to stretch in the living cell
Universal physical responses to stretch in the living cell
复制标题
DOI：
10.1038/nature05824
复制
发表时间：
2007-05-31
期刊：
影响因子：
64.8
通讯作者：
Fredberg, Jeffrey J.
中科院分区：
文献类型：
--
作者：
Trepat, Xavier;Deng, Linhong;Fredberg, Jeffrey J.
随着心脏的每一次跳动，肺的膨胀或肠道的扩张，具有不同功能的细胞类型都会受到大量的拉伸。拉伸是生长、分化、迁移、重塑和基因表达的有力刺激（1，2）。在这里，我们报告说，在响应瞬态拉伸的细胞骨架流化在这样一种方式，以定义一个通用的响应类。这一发现不仅涉及特定的信号中间体介导的机制，通常假设，但也通过一个缓慢发展的物理力量网络的非特异性行动。这些结果支持了这样一种观点，即细胞内部既是一个拥挤的化学空间（3），又是一种脆弱的软材料，其中生物化学、分子拥挤和物理力的影响是复杂的，不可分割的，但它们却共同产生了非常简单的现象学定律。这些定律似乎既普遍又原始，因此构成了细胞生物学和软物质物理学世界之间的一个引人注目的交叉点。
With every beat of the heart, inflation of the lung or peristalsis of the gut, cell types of diverse function are subjected to substantial stretch. Stretch is a potent stimulus for growth, differentiation, migration, remodelling and gene expression(1,2). Here, we report that in response to transient stretch the cytoskeleton fluidizes in such a way as to define a universal response class. This finding implicates mechanisms mediated not only by specific signalling intermediates, as is usually assumed, but also by non-specific actions of a slowly evolving network of physical forces. These results support the idea that the cell interior is at once a crowded chemical space(3) and a fragile soft material in which the effects of biochemistry, molecular crowding and physical forces are complex and inseparable, yet conspire nonetheless to yield remarkably simple phenomenological laws. These laws seem to be both universal and primitive, and thus comprise a striking intersection between the worlds of cell biology and soft matter physics.