NUTRITION OF THE INTERVERTEBRAL-DISK - SOLUTE TRANSPORT AND METABOLISM
NUTRITION OF THE INTERVERTEBRAL-DISK - SOLUTE TRANSPORT AND METABOLISM
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DOI：
10.3109/03008208109152130
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发表时间：
1981-01-01
影响因子：
2.9
通讯作者：
NACHEMSON, A
中科院分区：
文献类型：
--
作者：
HOLM, S;MAROUDAS, A;NACHEMSON, A
研究了不同氧张力下白天髓核的代谢情况。即使在高氧气压力下，新陈代谢也主要是无氧的，只有大约 1.5% 的葡萄糖转化为二氧化碳。 O2 消耗的浓度依赖性仅限于非常低的 O2 张力。利用扩散理论，利用氧气消耗和乳酸产生的值来计算髓核内这些物质的浓度分布。将预测的浓度分布与圆盘中不同位置的浓度的实验测量值进行比较。在细胞核中发现的这些值的良好一致性证实了代谢物转运的主要机制是扩散，并且营养物质供应到细胞核的主要途径是通过终板。
The metabolism of the day nucleus pulposus was investigated at different O2 tensions. Even at high O2 tensions metabolism is mainly anaerobic, only approximately 1.5% of the glucose being converted to CO2. The concentration dependence of O2 consumption is limited to very low O2 tensions. Values of O2 consumption and lactic acid production were used to calculate the concentration profiles of these substances within the nucleus pulposus, using a diffusion theory. The predicted concentration profiles were compared to the experimental measurements of concentration at various positions in the disc. The good agreement in these values found in the nucleus confirms that the main mechanism of metabolite transport is diffusion, and the main route of nutrient supply into the nucleus is via the endplate.