Risk Factors Associated with Ebola and Marburg Viruses Seroprevalence in Blood Donors in the Republic of Congo
Risk Factors Associated with Ebola and Marburg Viruses Seroprevalence in Blood Donors in the Republic of Congo
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DOI：
10.1371/journal.pntd.0003833
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发表时间：
2015-06-01
影响因子：
3.8
通讯作者：
de Lamballerie, Xavier
中科院分区：
文献类型：
--
作者：
Moyen, Nanikaly;Thirion, Laurence;de Lamballerie, Xavier
埃博拉和马尔堡病毒（丝状病毒科，埃博拉病毒属和马尔堡病毒属）引起人类出血热，通常与高死亡率相关。据报告，在一些非洲国家，没有出血热病史的个人中存在埃博拉病毒（EBOV）和马尔堡病毒（MARV）抗体。在这项研究中，我们提出了一个MARV和EBOV血清阳性率的研究中进行的献血者在刚果共和国和EBOV接触的危险因素的分析。方法和结果在2011年，我们进行了MARV和EBOV血清阳性率的研究中招募的809名献血者在农村（75; 9.3%）和城市（734; 90.7%）地区的刚果共和国。用间接免疫荧光双镜法检测血清中MARV和EBOV IgG抗体滴度。MARV血清阳性率为0.5%（4/809），无任何确定的危险因素。埃博拉病毒IgG感染率为2.5%，农村地区和黑角最高，为4%。多变量分析确定的独立风险因素与蝙蝠接触和暴露于birds.Conclusions/Significance这MARV和EBOV血清学调查在刚果共和国进行确定一个可能的作用，暴露于EBOV的环境决定因素。它强调了扩大我们对蝙蝠（以前被确定为潜在的生态水库）和鸟类作为EBOV对人类的载体的生态和流行病学风险的理解的必要性，并描述了在献血者中检测到的EBOV特异性抗体可能提供的保护。
Background Ebola and Marburg viruses (family Filoviridae, genera Ebolavirus and Marburgvirus) cause haemorrhagic fevers in humans, often associated with high mortality rates. The presence of antibodies to Ebola virus (EBOV) and Marburg virus (MARV) has been reported in some African countries in individuals without a history of haemorrhagic fever. In this study, we present a MARV and EBOV seroprevalence study conducted amongst blood donors in the Republic of Congo and the analysis of risk factors for contact with EBOV.Methodology and Findings In 2011, we conducted a MARV and EBOV seroprevalence study amongst 809 blood donors recruited in rural (75; 9.3%) and urban (734; 90.7%) areas of the Republic of Congo. Serum titres of IgG antibodies to MARV and EBOV were assessed by indirect double-immunofluorescence microscopy. MARV seroprevalence was 0.5% (4 in 809) without any identified risk factors. Prevalence of IgG to EBOV was 2.5%, peaking at 4% in rural areas and in Pointe Noire. Independent risk factors identified by multivariate analysis were contact with bats and exposure to birds.Conclusions/Significance This MARV and EBOV serological survey performed in the Republic of Congo identifies a probable role for environmental determinants of exposure to EBOV. It highlights the requirement for extending our understanding of the ecological and epidemiological risk of bats (previously identified as a potential ecological reservoir) and birds as vectors of EBOV to humans, and characterising the protection potentially afforded by EBOV-specific antibodies as detected in blood donors.