Increased Sensitivity to Low Concentration Gadolinium Contrast by Optimized Heavily T2-weighted 3D-FLAIR to Visualize Endolymphatic Space
Increased Sensitivity to Low Concentration Gadolinium Contrast by Optimized Heavily T2-weighted 3D-FLAIR to Visualize Endolymphatic Space
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DOI：
10.2463/mrms.9.73
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发表时间：
2010-01-01
影响因子：
3
通讯作者：
Nakashima, Tsutomu
中科院分区：
文献类型：
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作者：
Naganawa, Shinji;Kawai, Hisashi;Nakashima, Tsutomu
目的：为了提高三维液体衰减反转恢复(3D-FLAIR)对低浓度Gd造影剂的敏感性，我们对体模上的序列参数进行了优化，并对可疑内淋巴积水的患者进行了评估。材料和方法：所有扫描均在3Tesla磁共振(MR)设备上进行，使用32通道磁头线圈。我们使用一个填充了稀释Gd的体模来优化序列参数，并将优化后的协议与使用传统Turbo自旋回波序列的3D-FLAIR序列(3D-FLAIR-CONY)进行了比较。9例患者在静脉注射双剂量Gd后4小时，使用新优化的序列和3D-FLAIR-CONY进行扫描。结果：体模研究的最佳序列为：重复时间9000ms；回声时间540ms；翻转时间2400ms；低恒定读出翻转角120度。图像对比度增强T-2加权(HT(2)W-3D-FLAIR)。在患者中，我们通过hT2W-3D-FLAIR比3D-FLAIR-CONY更好地识别耳蜗和前庭的内淋巴间隙(P<；0.01)。新方法的平均CNR也好于3D-FLAIR-COV(P<；0.01)。结论：新优化的hT2W-3D-FLAIR方法对低浓度Gd的敏感性高于以前的方法。使用HT(2)W-3D-FLAIR双剂量静脉注射Gd显示内淋巴间隙更为可靠。
Purpose: To increase the sensitivity of 3-dimensional fluid-attenuated inversion recovery (3D-FLAIR) to low concentration gadolinium (Gd)-based contrast medium, we optimized sequence parameters on a phantom and evaluated the optimized sequence in patients suspicious for endolymphatic hydrops.Materials and Methods: All scans were performed on a 3-tesla magnetic resonance (MR) unit using a 32-channel head coil. We optimized sequence parameters using a phantom filled with diluted Gd and compared the optimized protocol with 3D-FLAIR using conventional turbo spin echo sequence (3D-FLAIR-CONY). Nine patients underwent scanning using the newly optimized sequence and 3D-FLAIR-CONY 4 hours after double-dose administration of intravenous Gd. We subjectively scored separation of endo- and perilymph space and measured contrast-to-noise ratio (CNR) between endo- and perilymph.Results: The optimized sequence in the phantom study consisted of: repetition time, 9000 ms; echo time, 540 ms; inversion time, 2400 ms; low constant readout flip angle, 120 degrees in the later part of the echo train. Image contrast became heavily T-2 weighted (hT(2)W-3D-FLAIR). In patients, we recognized endolymphatic space for both the cochlea and vestibule significantly better by hT2W-3D-FLAIR than 3D-FLAIR-CONY (P < 0.01). The mean CNR of the new method was also better than that of 3D-FLAIR-CONV (P < 0.01).Conclusions: The newly optimized hT2W-3D-FLAIR was more sensitive than the previous method to low concentration of Gd. Visualization of the endolymphatic space by double-dose administration of intravenous Gd would be more reliable using hT(2)W-3D-FLAIR.