Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model
Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model
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DOI：
10.1016/j.jneuroim.2005.08.012
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发表时间：
2005-12-01
影响因子：
3.3
通讯作者：
Pintér, E
中科院分区：
文献类型：
--
作者：
Bánvölgyi, A;Pálinkás, L;Pintér, E
本研究的目的是探讨瞬时受体电位香草酸受体1(TRPV1)在小鼠变态反应性接触性皮炎(ACD)炎症过程中的作用。恶唑酮诱导的ACD在24-72h后引起明显的耳肿胀，TRPV1基因敲除小鼠的耳廓肿胀在各个时间点都有所增加，并得到组织学分析和肿瘤坏死因子-α测定的支持。然而，在神经激肽I受体和降钙素基因相关肽(CGRP)基因敲除的小鼠中，组织肿胀和细胞因子的产生都显著减少。在接触性皮炎中发现了TRPV1受体的保护性参与，与主要的促炎神经肽的机制不同。(C)2005 Elsevier B.V.保留所有权利。
The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-alpha. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin I receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides. (C) 2005 Elsevier B.V. All rights reserved.