Intrinsic Functional Connectivity in Salience and Default Mode Networks and Aberrant Social Processes in Youth at Ultra-High Risk for Psychosis.
Intrinsic Functional Connectivity in Salience and Default Mode Networks and Aberrant Social Processes in Youth at Ultra-High Risk for Psychosis.
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DOI：
10.1371/journal.pone.0134936
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Mittal VA
中科院分区：
文献类型：
--
作者：
Pelletier-Baldelli A;Bernard JA;Mittal VA
社会过程是导航世界的关键，调查其潜在机制和认知结构可以帮助理解精神分裂症等疾病状态，其中社会过程受到高度影响。有证据表明，社会过程在精神病发展（UHR）的超高风险个体中受损。了解UHR青年的这些现象可以澄清疾病的病因和社会进程，这一时期的特点是比精神分裂症的混淆少得多。此外，了解这一人群的社会加工缺陷将有助于解释健康个体的这些过程。目前的研究在UHR个体和健康对照中检测了与面部情绪识别（FER）相关的显著性（SN）和默认模式网络（DMN）的静息状态连通性，这是社会过程的一个组成部分，以及更广泛的社会功能（SF）。与现有文献一致，与对照组相比，UHR青年在FER和SF方面受损。在UHR组中，我们发现SN与内侧前额叶皮层（DMN的一个区域）之间的连通性增加。在UHR青年中，DMN分别与体感觉皮层/小脑和楔前叶表现出正相关和负相关，这与更好的FER表现有关。对于SF，结果表明，感觉加工与SN的联系可能对两组的SF都很重要，但特别是在感觉加工可能未受损的对照组中。这些发现阐明了社会加工缺陷如何在精神病中表现出来，并强调了SN和DMN连接对社会加工的重要性。
Social processes are key to navigating the world, and investigating their underlying mechanisms and cognitive architecture can aid in understanding disease states such as schizophrenia, where social processes are highly impacted. Evidence suggests that social processes are impaired in individuals at ultra high-risk for the development of psychosis (UHR). Understanding these phenomena in UHR youth may clarify disease etiology and social processes in a period that is characterized by significantly fewer confounds than schizophrenia. Furthermore, understanding social processing deficits in this population will help explain these processes in healthy individuals. The current study examined resting state connectivity of the salience (SN) and default mode networks (DMN) in association with facial emotion recognition (FER), an integral aspect of social processes, as well as broader social functioning (SF) in UHR individuals and healthy controls. Consistent with the existing literature, UHR youth were impaired in FER and SF when compared with controls. In the UHR group, we found increased connectivity between the SN and the medial prefrontal cortex, an area of the DMN relative to controls. In UHR youth, the DMN exhibited both positive and negative correlations with the somatosensory cortex/cerebellum and precuneus, respectively, which was linked with better FER performance. For SF, results showed that sensory processing links with the SN might be important in allowing for better SF for both groups, but especially in controls where sensory processing is likely to be unimpaired. These findings clarify how social processing deficits may manifest in psychosis, and underscore the importance of SN and DMN connectivity for social processing more generally.