Polymorphonuclear neutrophils: an effective antimicrobial force.
Polymorphonuclear neutrophils: an effective antimicrobial force.
复制标题
DOI：
10.1093/clinids/11.supplement_7.s1532
复制
发表时间：
1989-11
期刊：
影响因子：
--
通讯作者：
Daniel W. Sawyer;G. Donowitz;G. L. Mandell
中科院分区：
文献类型：
--
作者：
Daniel W. Sawyer;G. Donowitz;G. L. Mandell
多形核中性粒细胞 (PMN) 的产生和部署受到严格监管。 PMN 通过细胞因子与多种细胞类型相互作用，包括巨噬细胞、淋巴细胞和内皮细胞。 PMN 在细菌产物和细胞因子的引导下到达目标位点，在那里微生物被识别并杀死。杀伤通过氧依赖性和氧非依赖性机制发生。在 PMN 功能缺陷（先天性或后天性）的患者中观察到的频繁且严重的感染证明了 PMN 在宿主防御感染中的重要性。 PMN 是强效炎症细胞，可加剧心肌缺血、革兰氏阴性细菌败血症和成人呼吸窘迫综合征等疾病状态。
The production and deployment of polymorphonuclear neutrophils (PMNs) are under close regulation. PMNs interact through cytokines with a number of cell types, including macrophages, lymphocytes, and endothelial cells. PMNs are guided by bacterial products and cytokines to target sites, where microbes are recognized and killed. Killing occurs through oxygen-dependent and oxygen-independent mechanisms. The frequent and severe infections seen in patients with defects (either congenital or acquired) in PMN function demonstrate the importance of PMNs in host defense against infection. PMNs are potent inflammatory cells and can exacerbate disease states such as myocardial ischemia, gram-negative bacterial sepsis, and the adult respiratory distress syndrome.