Comparison of diclofenac and fluorometholone in preventing cystoid macular edema after small incision cataract surgery: A multicentered prospective trial
Comparison of diclofenac and fluorometholone in preventing cystoid macular edema after small incision cataract surgery: A multicentered prospective trial
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DOI：
10.1016/s0021-5155(99)00176-8
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发表时间：
2000-01-01
影响因子：
2.4
通讯作者：
Hayashi, F
中科院分区：
文献类型：
--
作者：
Miyake, K;Masuda, K;Hayashi, F
目的：比较非甾体局部溶液（0.1%双氯芬酸），甾体局部溶液（0.1%氟米龙）在预防黄斑囊样水肿（CME）和破坏的blood-aqueous barrier.Methods：一个多中心，前瞻性临床试验的眼睛进行超声乳化白内障吸除术，然后植入一个可折叠的丙烯酸人工透镜的信封技术。囊样黄斑水肿（CME）的存在和程度通过荧光素血管造影确定。通过激光闪光细胞光度法测定的血-房水屏障的击穿。结果：手术后5周，CME存在于3的53只眼睛（5.7%）接受二氯芬酸和29的53只眼睛（54.7%）接受氟米龙。这种差异具有统计学意义（P < .001）。术后3天、1、2、5和8周时，双氯芬酸组的前房闪辉量也显著较低（P <0.01-P <0.001）。术后3天、1周、2周、5周和8周CME患者的闪光程度明显高于对照组（P <0.001）。结论：双氯芬酸可有效预防白内障术后CME的发生，CME与血-房水屏障的破坏密切相关。(C)2000年日本眼科学会。
Purpose: To compare a nonsteroidal topical solution (0.1% diclofenac) to a steroidal topical solution (0.1% fluorometholone) in preventing cystoid macular edema (CME) and disruption of the blood-aqueous barrier.Methods: A multicentered, prospective clinical trial was performed on eyes undergoing phacoemulsification followed by implantation of a foldable acrylic intraocular lens by the envelope technique. The presence and degree of cystoid macula edema (CME) was determined by fluorescein angiography. A breakdown of the blood-aqueous barrier was determined by laser flare-cell photometry.Results: Five weeks after surgery, CME was present in 3 of 53 eyes (5.7%) receiving di clofenac and in 29 of 53 eyes (54.7%) receiving fluorometholone. This difference was statistically significant (P < .001). The amount of flare in the anterior chamber at 3 days, 1, 2, 5, and 8 weeks after surgery was also significantly lower (P < .01-P < .001) in the diclofenac group. The degree of flare at 3 days, 1, 2, 5 and 8 weeks after surgery was significantly higher in eyes with CME (P < .001).Conclusions: These findings suggest that diclofenac effectively prevents CME following cataract surgery and that CME is closely related to the breakdown of the blood-aqueous barrier. (C) 2000 Japanese Ophthalmological Society.