Impaired fasting glucose prevalence in two nationwide cohorts of obese children and adolescents
Impaired fasting glucose prevalence in two nationwide cohorts of obese children and adolescents
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DOI：
10.1038/ijo.2013.124
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发表时间：
2014-01-01
影响因子：
4.9
通讯作者：
Holl, R. W.
中科院分区：
文献类型：
--
作者：
Hagman, E.;Reinehr, T.;Holl, R. W.
目的：空腹血糖受损（IFG）是成人2型糖尿病的前期，也存在于肥胖儿童中。已记录到发生率的较大变化，但由于缺乏较大的代表性队列研究，因此尚不清楚真实的患病率。本研究旨在调查IFG在两个全国性肥胖儿童队列中的患病率，并寻找影响IFG.DESIGN风险的因素：一项横断面研究，基于从德国和瑞典的两个全国性肥胖儿童登记处收集的数据，分别。德国有32907例空腹血糖受试者合格，瑞典有2726例合格。IFG有两个截止值：根据美国糖尿病协会（ADA）的5.6-6.9 mmol l（-1）和根据世界卫生组织（WHO）的6.1-6.9 mmol l（-1）。收集的变量包括性别、年龄和肥胖程度。Logistic回归分析用于计算比值比。结果：根据ADA，德国队列中肥胖儿童IFG的总患病率为5.7%，根据WHO为1.1%。在瑞典，相应的患病率分别为17.1%和3.9%。IFG风险与年龄、男性和肥胖程度的增加相关。结论：IFG在肥胖儿童中非常普遍。年龄和肥胖程度与IFG的风险呈正相关。区域差异很大。经过调整后，瑞典的肥胖儿童，由于不明原因，患IFG的风险比德国的肥胖儿童高3.4至3.7倍。
OBJECTIVE: Impaired fasting glucose (IFG), a pre-stage to type 2 diabetes in adults, is also present in obese children. A large variation of the occurrence has been recorded, but the true prevalence is unknown due to lack of larger representative cohort studies. This study was implemented to investigate the prevalence of IFG in two nationwide cohorts of obese children and to find factors that affect the risk of IFG.DESIGN: A cross-sectional study based on data collected from two nationwide registers of obese children in Germany and Sweden, respectively.SUBJECTS: Subjects included were 2-18 years old. 32 907 subjects with fasting glucose were eligible in Germany and 2726 in Sweden. Two cutoff limits for IFG were used: 5.6-6.9 mmol l(-1) according to the American Diabetes Association (ADA) and 6.1-6.9 mmol l(-1) according to the World Health Organization (WHO). Variables collected were gender, age and degree of obesity. Logistic regression was used to calculate odds ratios.RESULTS: The total prevalence of IFG among obese children in the German cohort according to the ADA was 5.7% and according to the WHO it was 1.1%. In Sweden, the corresponding prevalence was 17.1% and 3.9%, respectively. IFG risk was correlated with increasing age, male sex and degree of obesity.CONCLUSIONS: IFG is highly prevalent among obese children. Age and degree of obesity are positively correlated with the risk of having IFG. There are large regional differences. After adjustments, obese children in Sweden, due to unknown reasons, have a 3.4- to 3.7-fold higher risk of having IFG than obese children in Germany.