Regulation of platelet-fibrin thrombi on subendothelium.
Regulation of platelet-fibrin thrombi on subendothelium.
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内皮下血小板纤维蛋白血栓的调节。
DOI：
10.1111/j.1749-6632.1987.tb33057.x
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发表时间：
1987
影响因子：
5.2
通讯作者：
Turitto,VT
中科院分区：
文献类型：
--
作者：
Weiss,HJ;Baumgartner,HR;Turitto,VT
正常止血和病理性血栓形成的部分原因是血管损伤部位形成的血小板-纤维蛋白血栓。我们利用Baumgartner开发的一项技术研究了这一过程，该技术用于在受控流动条件下将去内皮的兔主动脉节段暴露于人血中。最初，我们的研究集中在影响血小板在内皮下层沉积的因素。最近，我们利用这项技术来研究纤维蛋白沉积。这些研究的结果表明，血小板和纤维蛋白在内皮下层的沉积强烈地受到血浆和细胞因素、血管壁特性和血流的影响。
Both normal hemostasis and pathological thrombosis are due, in part, to the formation of platelet-fibrin thrombi at sites of blood vessel injury. We have studied this process utilizing a technique developed by Baumgartner'for exposing de-endothelialized segments of rabbit aorta to human blood under controlled flow conditions. Initially our studies focused on factors that influence the deposition of platelets on the subendothelium. More recently, we have utilized this technique for studying fibrin deposition. The results of these studies have demonstrated that platelet and fibrin deposition on the subendothelium are strongly influenced by plasma and cellular factors, by properties of the vessel wall, and by flow.