Influence of exercise on the immune function of rats of various ages.
Influence of exercise on the immune function of rats of various ages.
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运动对不同年龄大鼠免疫功能的影响
DOI：
10.1152/jappl.1988.64.5.1997
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Richardson,A
中科院分区：
文献类型：
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作者：
Pahlavani,MA;Cheung,TH;Chesky,JA;Richardson,A
这项研究的目的是确定运动是否可以预防与年龄相关的有丝分裂的下降，这在大鼠，小鼠和人类中已有很好的记录。在1、6、12和18月龄时，雄性Fischer F344大鼠每天进行游泳运动，持续6个月。在6个月的训练期结束时，脾淋巴细胞分离出运动大鼠和年龄匹配的久坐不动的对照。用有丝分裂原伴刀豆球蛋白A（ConA）和脂多糖（LPS）测定淋巴细胞增殖的诱导作用。此外，淋巴细胞产生白细胞介素2（IL 2）的能力，在ConA诱导进行了测量。ConA和LPS诱导的增殖下降41-63%之间的7和25个月的年龄在运动和久坐的对照组大鼠。ConA诱导的IL-2的产生在7 ~ 25月龄的运动和久坐对照组大鼠中分别下降了42%和62%。虽然与年龄相关的有丝分裂原诱导的增殖和IL 2的产生下降较小的运动大鼠，这是由于较低水平的有丝分裂和IL 2的产生淋巴细胞从年轻的运动大鼠。与7个月大的安静大鼠相比，运动导致7个月大的运动大鼠的有丝分裂原诱导的淋巴细胞增殖和IL-2产生显著降低（23-32%）。然而，在18月龄和24月龄的大鼠中，有丝分裂原诱导的淋巴细胞增殖和IL 2的产生在运动和久坐对照大鼠之间没有显著差异。
The purpose of this study was to determine whether exercise could prevent the age-related decline in mitogenesis, which has been well documented in rats, mice, and humans. At 1, 6, 12, and 18 mo of age, male Fischer F344 rats were subjected daily to swimming exercise for 6 mo. At the end of the 6-mo training period, spleen lymphocytes were isolated from the exercised rats and from age-matched sedentary controls. The induction of lymphocyte proliferation was measured with the mitogens concanavalin A (ConA) and lipopolysaccharide (LPS). In addition, the ability of the lymphocytes to produce interleukin 2 (IL 2) in response to ConA induction was measured. ConA- and LPS-induced proliferation decreased 41–63% between 7 and 25 mo of age in both exercised and sedentary control rats. ConA-induced IL 2 production decreased 42 and 62% between 7 and 25 mo of age for exercised and sedentary control rats, respectively. Although the age-related decline in mitogen-induced proliferation and IL 2 production was smaller in exercised rats, this was due to a lower level of mitogenesis and IL 2 production in lymphocytes from young exercised rats. Exercise resulted in a significant decrease (23–32%) in mitogen-induced lymphocyte proliferation and IL-2 production in 7-mo-old exercised rats compared with 7-mo-old sedentary rats. However, in the 18- and 24-mo-old rats, mitogen-induced lymphocyte proliferation and IL 2 production was not significantly different between exercised and sedentary control rats.