The role of hypoxia-inducible factor-2 in digestive system cancers.
The role of hypoxia-inducible factor-2 in digestive system cancers.
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缺氧诱导因子2在消化系统癌症中的作用
DOI：
10.1038/cddis.2014.565
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发表时间：
2015-01-15
影响因子：
9
通讯作者：
Xu B
中科院分区：
文献类型：
--
作者：
Zhao J;Du F;Shen G;Zheng F;Xu B
缺氧是癌症中几乎普遍存在的现象。两种已知的缺氧诱导因子 (HIF)：HIF-1α 和 HIF-2α，主要介导缺氧的转录反应。尽管 HIF-1α 和 HIF-2α 之间具有高度同源性，但新的证据表明这两种分子在转录靶标以及对多种生理途径和肿瘤发生的影响方面存在差异。迄今为止，在了解 HIF-2α 在消化系统癌症中的作用方面已经取得了很大进展。事实上，HIF-2α已被证明可以调节消化系统癌症的多个方面，包括细胞增殖、血管生成和凋亡、代谢、转移和化疗耐药。这些发现使 HIF-2α 成为这种恶性表型的关键调节因子。在这里，我们总结了 HIF-2 在癌症发展过程中的功能及其对消化系统恶性肿瘤发生的贡献。
Hypoxia is an all but ubiquitous phenomenon in cancers. Two known hypoxia-inducible factors (HIFs), HIF-1α and HIF-2α, primarily mediate the transcriptional response to hypoxia. Despite the high homology between HIF-1α and HIF-2α, emerging evidence suggests differences between both molecules in terms of transcriptional targets as well as impact on multiple physiological pathways and tumorigenesis. To date, much progress has been made toward understanding the roles of HIF-2α in digestive system cancers. Indeed, HIF-2α has been shown to regulate multiple aspects of digestive system cancers, including cell proliferation, angiogenesis and apoptosis, metabolism, metastasis and resistance to chemotherapy. These findings make HIF-2α a critical regulator of this malignant phenotype. Here we summarize the function of HIF-2 during cancer development as well as its contribution to tumorigenesis in digestive system malignancies.