Mycobacterium tuberculosis infection as a zoonotic disease: Transmission between humans and elephants
Mycobacterium tuberculosis infection as a zoonotic disease: Transmission between humans and elephants
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DOI：
10.3201/eid0402.980217
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发表时间：
1998-04-01
影响因子：
11.8
通讯作者：
Maslow, JN
中科院分区：
文献类型：
--
作者：
Michalak, K;Austin, C;Maslow, JN
1994年至1996年间，来自伊利诺伊州一个外来动物农场的三头大象死于结核分枝杆菌引起的肺部疾病。 1996 年 10 月，第四头活象结核分枝杆菌培养呈阳性。农场的 22 名饲养员接受了结核病 (TB) 筛查； 11 名患者对皮内注射纯化蛋白衍生物呈阳性反应。一名患者涂片阴性、培养阳性的活动性结核病。通过 IS6110 和 TBN12 分型进行的 DNA 指纹比对表明，四头大象和患有活动性结核病的驯象人分离出的菌株是同一菌株。这项调查表明结核分枝杆菌在人类和大象之间传播。
Between 1994 and 1996, three elephants from an exotic animal farm in Illinois died of pulmonary disease due to Mycobacterium tuberculosis. In October 1996, a fourth living elephant was culture-positive for M. tuberculosis. Twenty-two handlers at the farm were screened for tuberculosis (TB); eleven had positive reactions to intradermal injection with purified protein derivative. One had smear-negative, culture-positive active TB. DNA fingerprint comparison by IS6110 and TBN12 typing showed that the isolates from the four elephants and the handler with active TB were the same strain. This investigation indicates transmission of M. tuberculosis between humans and elephants.