Regulation of angiogenesis in malignant gliomas.
Regulation of angiogenesis in malignant gliomas.
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恶性神经胶质瘤中血管生成的调节。
DOI：
10.1007/978-3-0348-9006-9_4
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发表时间：
1997
期刊：
影响因子：
--
通讯作者：
Laterra,J
中科院分区：
文献类型：
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作者：
Guerin,C;Laterra,J
胶质瘤对传统治疗措施具有高度抵抗力，需要开发新的治疗方法。由于胶质瘤是一种特殊的血管肿瘤，一种方法涉及针对抑制血管生成机制的治疗。尽管多种因素对任何肿瘤的最终血管形成都有贡献，但有些因素与胶质瘤尤其相关。针对抑制血管生成途径的早期实验工作显示出实现对肿瘤生长的控制的希望。本文就血管生成及相关的血管细胞反应在脑胶质瘤生物学中的重要作用的证据进行综述，并对已知的参与脑胶质瘤血管反应的生化途径进行综述。最后，当代血管靶向方法已被用来抑制胶质瘤生长进行了讨论。
Gliomas are highly resistant to conventional therapeutic measures, requiring the development of novel treatments. Since gliomas are particularly vascular tumors, one approach involves treatments directed at inhibiting angiogenic mechanisms. Although multiple factors contribute to the ultimate vascularization of any tumor, some are especially relevant to gliomas. Early experimental work directed at inhibiting angiogenic pathways has shown promise toward achieving control of tumor growth. This article focuses on the evidence that angiogenesis and related vascular cell responses play important roles in glioma biology, and reviews those biochemical pathways known through experimentation to be involved in the vascular response to gliomas. Finally, contemporary vessel-targeted approaches that have been used to inhibit glioma growth are discussed.