Masturbation Frequency and Sexual Function Domains Are Associated With Serum Reproductive Hormone Levels Across the Menopausal Transition
Masturbation Frequency and Sexual Function Domains Are Associated With Serum Reproductive Hormone Levels Across the Menopausal Transition
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DOI：
10.1210/jc.2014-1725
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发表时间：
2015-01-01
影响因子：
5.8
通讯作者：
Harlow, Sioban D.
中科院分区：
文献类型：
--
作者：
Randolph, John F., Jr.;Zheng, Huiyong;Harlow, Sioban D.
目的：探讨绝经过渡期生殖激素与性功能的关系。设计：全国妇女健康研究（SWAN）是一项位于美国七个地点的绝经期过渡的多民族队列研究。在基线时，3302名42-52岁的社区参与者有完整的子宫和至少一个卵巢，并且没有使用外源性激素。参与者自我认同为白人、黑人、西班牙人、中国人或日本人。在基线和10次随访中，性功能通过自我管理的问卷进行评估，并抽血测定血清T、雌二醇、卵泡刺激素、SHBG和硫酸脱氢表雄酮水平。主要结局指标：自我报告的自慰频率、性欲、性唤起、性高潮和性交疼痛。结果：自慰、性欲和性兴奋与t呈正相关，自慰、性兴奋和性高潮与FSH呈负相关。关联不大。雌二醇与任何测量的性功能领域无关。性交疼痛与任何激素无关。结论：生殖激素与中年女性性功能相关。T正相关，支持雄激素在女性性功能中的作用。FSH呈负相关，支持更年期状态对女性性功能的作用。这项大型研究的适度关联表明，这种关系是微妙的，可能具有有限的临床意义。
Objective: To determine whether reproductive hormones are related to sexual function during the menopausal transition.Design: The Study of Women's Health Across the Nation (SWAN) is a multiethnic cohort study of the menopausal transition located at seven US sites. At baseline, the 3302 community-based participants, aged 42-52, had an intact uterus and at least one ovary and were not using exogenous hormones. Participants self-identified as White, Black, Hispanic, Chinese, or Japanese. At baseline and at each of the10follow-upvisits, sexual function was assessed by self-administered questionnaires, and blood was drawn to assay serum levels of T, estradiol, FSH, SHBG, and dehydroepiandrosterone sulfate.Main Outcome Measures: Self-reported frequency of masturbation, sexual desire, sexual arousal, orgasm, and pain during intercourse.Results: Masturbation, sexual desire, and arousal were positively associated with T. Masturbation, arousal, and orgasm were negatively associated with FSH. Associations were modest. Estradiol was not related to any measured sexual function domain. Pain with intercourse was not associated with any hormone.Conclusions: Reproductive hormones were associated with sexual function in midlife women. T was positively associated, supporting the role of androgens in female sexual function. FSH was negatively associated, supporting the role of menopausal status in female sexual function. The modest associations in this large study suggest that the relationships are subtle and may be of limited clinical significance.