Abnormal mucociliary transport in allergic patients with antigen-induced bronchospasm: role of slow reacting substance of anaphylaxis.
Abnormal mucociliary transport in allergic patients with antigen-induced bronchospasm: role of slow reacting substance of anaphylaxis.
复制标题
抗原诱导的支气管痉挛过敏患者粘液纤毛运输异常：过敏反应慢反应物质的作用。
DOI：
10.1164/arrd.1981.124.2.110
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Wanner,A
中科院分区：
文献类型：
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作者：
Ahmed,T;Greenblatt,DW;Birch,S;Marchette,B;Wanner,A
我们评估了过敏性反应慢反应物质（SRS-A）在过敏性哮喘中介导粘膜纤毛功能障碍的可能作用。在6例无症状的豚草哮喘非吸烟者中，我们测量了豚草提取物在支气管刺激前后的特定气道电导（SGaw）和气管粘膜速度（TMV），分别用0.5%和1%的fsl -55712 （SRS-A拮抗剂）进行预处理。平均基线TMV为8.9 mm/min （SD, 1.1）。安慰剂和FPL-55712本身对TMV没有影响。与剂量的安慰剂预处理豚草提取,导致从基线SGaw下降超过35%,导致烟草花叶病毒立即减少基线的74% (p < 0.05),回到基线fpl在2 h。0.5%和1% - 55712预处理,剂量的豚草提取,导致类似的减少SGaw导致增加TMV基线的130%和126% (p < 0.05),分别后,回到基线2 h postchallenge抗原的挑战。抗原激发后立即吸入1% FPL-55712可阻止TMV的下降。这些结果表明：(a)气道过敏反应过程中释放的SRS-A损害了粘膜运输，(b)抗原诱导的TMV增加经SRS-A拮抗剂预处理后可能反映了其他过敏反应化学介质的刺激作用。
We evaluated the possible role of slow reacting substance of anaphylaxis (SRS-A) in mediating mucociliary dysfunction in allergic asthma. In 6 asymptomatic nonsmokers with ragweed asthma, we measured specific airway conductance (SGaw) and tracheal mucous velocity (TMV) before and after bronchial challenge with ragweed extract, with or without pretreatment with 0.5% and 1% FPL-55712 (SRS-A antagonist). Mean baseline TMV was 8.9 mm/min (SD, 1.1). Placebo and FPL-55712 per se had no effect on TMV. With placebo pretreatment, the doses of ragweed extract that resulted in a decrease in SGaw by more than 35% from baseline, led to an immediate decrease in TMV to 74% of baseline (p < 0.05), returning to baseline within 2 h. With 0.5% and 1% FPL-55712 pretreatment, doses of ragweed extract that resulted in a similar decrease in SGaw led to an increase in TMV to 130% and 126% of baseline (p < 0.05), respectively, immediately after antigen challenge and returned to baseline 2 h postchallenge. Inhalation of 1% FPL-55712 immediately after antigen challenge prevented the decrease in TMV. These results indicated that (a) SRS-A liberated during airway anaphylaxis impairs mucous transport, and (b) the antigen-induced increase in TMV after pretreatment with an SRS-A antagonist may reflect a stimulatory effect of other chemical mediators of anaphylaxis.