Somatocrinin, growth hormone releasing factor, stimulates secretion of growth hormone in anesthetized rats.
Somatocrinin, growth hormone releasing factor, stimulates secretion of growth hormone in anesthetized rats.
复制标题
生长激素释放因子，生长激素释放因子，刺激麻醉大鼠生长激素的分泌。
DOI：
10.1016/0006-291x(82)91732-6
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发表时间：
1982
影响因子：
3.1
通讯作者：
Guillemin,R
中科院分区：
文献类型：
--
作者：
Wehrenberg,WB;Ling,N;Brazeau,P;Esch,F;Böhlen,P;Baird,A;Ying,S;Guillemin,R
从引起肢端肥大症的人胰腺肿瘤中分离的44个氨基酸的肽的合成复制品具有在麻醉的雄性大鼠中释放生长激素（GH）的高比活性。由该肽诱导的GH分泌在50 ng至1 μg范围内呈剂量依赖性，在较高剂量下静脉给药5 min内血浆GH浓度增加10倍以上。还分离了44个残基肽的两种酶促降解产物，其由前37和40个氨基酸组成。所有三种肽似乎具有相似的效力，在摩尔的基础上，在体内，在体外结果相反。这些肽对GH释放的特异性表现为它们不能改变催乳素（PRL）、促甲状腺激素（TSH）、促黄体激素（LH）、促卵泡激素（FSH）和皮质酮的血浆浓度。基于这些体内结果，这三种肽可作为研究GH分泌机制的有力工具。
The synthetic replicate of a 44 amino acid peptide isolated from a human pancreatic tumor which had caused acromegaly possesses high specific activity to release growth hormone (GH) in anesthetized male rats. The GH secretion induced by this peptide is dose-dependent from 50 ng to 1 μg, with plasma GH concentrations increasing more than 10-fold within 5 min of iv administration at the higher doses. Two enzymatic degradation products of the 44 residue peptide were also isolated and consist of the first 37 and 40 amino acids. All three peptides appear to possess similar potency, on a molar basis, in vivo, contrary to in vitro results. The specificity of these peptides on GH release was shown by their failure to alter plasma concentrations of prolactin (PRL), thyroid-stimulating hormone (TSH), luteinizing hormone (LH), follicle-stimulating hormone (FSH) and corticosterone. Based on these in vivo results, the three peptides with serve as powerful tools with which to investigate the mechanisms of GH secretion.