Cytotoxicity, tumor targeting and PET imaging of sub-5 nm KGdF4 multifunctional rare earth nanoparticles
Cytotoxicity, tumor targeting and PET imaging of sub-5 nm KGdF4 multifunctional rare earth nanoparticles
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DOI：
10.1039/c5nr03374h
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发表时间：
2015-01-01
期刊：
影响因子：
6.7
通讯作者：
Li, Fuyou
中科院分区：
文献类型：
--
作者：
Cao, Xinmin;Cao, Fengwen;Li, Fuyou
超小的亚5纳米KGdF4稀土纳米粒子的合成作为多功能探针的荧光，磁性和放射性核素成像。这些纳米颗粒在人胶质母细胞瘤U87 MG和人非小细胞肺癌H1299细胞中的细胞毒性进行了评估，并且它们在体外和体内肿瘤靶向成像中的应用也得到了证实。
Ultrasmall sub-5 nm KGdF4 rare earth nanoparticles were synthesized as multifunctional probes for fluorescent, magnetic, and radionuclide imaging. The cytotoxicity of these nanoparticles in human glioblastoma U87MG and human non-small cell lung carcinoma H1299 cells was evaluated, and their application for in vitro and in vivo tumor targeted imaging has also been demonstrated.