Effects of perinatal combined exposure to 1,4-dichlorobenzene and 1,1-dichloro-2, 2-bis (p-chlorophenyl) ethylene on rat male offspring.
Effects of perinatal combined exposure to 1,4-dichlorobenzene and 1,1-dichloro-2, 2-bis (p-chlorophenyl) ethylene on rat male offspring.
复制标题
围产期联合暴露于 1,4-二氯苯和 1,1-二氯-2, 2-双（对氯苯基）乙烯对大鼠雄性后代的影响。
DOI：
10.1111/j.1742-7843.2004.950306.x
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发表时间：
2004
影响因子：
3.1
通讯作者：
Y. Makita
中科院分区：
文献类型：
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作者：
Y. Makita
1，4-二氯苯（DCB）是一种空气除臭剂或驱蛾剂，1，1-二氯-2，2-二（对氯苯基）乙烯（p，p'-DDE）是1，1，1-三氯-2，2-二（对氯苯基）乙烷（DDT）的持久性代谢产物。在日本，住宅空气和通过海产品摄入的口服p，p'-DDE中的DCB浓度非常高，因此，胎儿和新生儿可能通过母体暴露于DCB和/或p，p'-DDE。最近有报道称DCB具有雌激素活性，而p，p'-DDE具有抗雄激素活性。因此，在妊娠第1天至产后第21天的围产期期间，研究了母体暴露于DCB和p，p'-DDE的大鼠雄性后代中这些污染物的围产期暴露的综合影响，持续42天。在本研究中，母鼠经口给予25 ppm DCB（约2 mg/kg）和/或125 ppm p，p'-DDE（约10 mg/kg）后，未发现对雄性后代的明显发育影响，直至6周龄。与雌性后代相比，雄性后代的胸腺重量在6周龄时不受DCB的影响，但DCB对胸腺的影响可能存在性别差异。
1,4-Dichlorobenzene (DCB) is used as an air deodorant or a moth repellent and 1, 1-dichloro-2, 2-bis (p-chlorophenyl) ethylene (p,p'-DDE) is a persistent metabolite of 1, 1, 1-trichloro-2, 2-bis (p-chlorophenyl) ethane (DDT) which was used as a pesticide before. DCB concentrations of residential air and oral p,p'-DDE intake through marine products are demonstrated to be very high in Japan and consequently, foetuses and neonates may be exposed much more to DCB and/or p,p'-DDE via the maternal body. It has recently been reported that DCB is oestrogenic and that p,p'-DDE is antiandrogenic. Therefore, the combined effects of perinatal exposure to DCB and p,p'-DDE have been investigated in rat male offspring of dams ingesting these contaminants during the perinatal period from gestational day 1 to postpartum day 21 for 42 days. In this study, no obvious developmental effects on male offspring have been recognized until 6 weeks of age, following oral administration of 25 ppm DCB (approximately 2 mg/kg) and/or 125 ppm p,p'-DDE (approximately 10 mg/kg) to dams. In contrast to female offspring, the thymus weight in male offspring was not affected by DCB at 6 weeks of age, but there might be sexual differences concerning the effects of DCB on the thymus.