Effects of external magnetic field on biodistribution of nanoparticles: A histological study
Effects of external magnetic field on biodistribution of nanoparticles: A histological study
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DOI：
10.1016/j.jmmm.2006.10.1202
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发表时间：
2007-04-01
影响因子：
2.7
通讯作者：
Ma, Yunn-Hwa
中科院分区：
文献类型：
--
作者：
Wu, Tony;Hua, Mu-Yi;Ma, Yunn-Hwa
本研究探讨了外磁场对纳米粒子（NP）生物分布的影响。将2.4kG的NdFeB磁体外部施加在左股动脉或右肾上。将250 nm右旋糖酐包被的Fe3O4纳米粒经尾静脉注射到健康大鼠体内，1或24 h后取器官。普鲁士蓝染色显示，NP在肝、脾中的滞留速度快于肺。应用外部磁体后，在肾脏和股动脉中观察到的NP聚集具有时间依赖性。中空器官如肠、结肠和膀胱保留很少NP。(c)2007 Elsevier B.V.保留所有权利。
This study investigates the effect of external magnetic fields on the biodistribution of nanoparticles (NP). A NdFeB magnet of 2.4 kG was externally applied over the left femoral artery or right kidney. The 250 nm dextran-coated Fe3O4 NP was injected via tail vein in healthy rats, and organs were taken 1 or 24 h later. Prussian blue stain revealed that NP were more rapidly retained in the liver and spleen than in the lungs. NP aggregation observed in the kidney and femoral artery after application of external magnets was time dependent. Hollow organs such as the intestine, colon, and urinary bladder retained little NP. (c) 2007 Elsevier B.V. All rights reserved.