A Putative Multiple-Demand System in the Macaque Brain
A Putative Multiple-Demand System in the Macaque Brain
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DOI：
10.1523/jneurosci.0810-16.2016
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发表时间：
2016-08-17
影响因子：
5.3
通讯作者：
Duncan, John
中科院分区：
文献类型：
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作者：
Mitchell, Daniel J.;Bell, Andrew H.;Duncan, John
在人类中，许多类型的认知要求较高的任务都会占用共同的额顶脑区域。这种“多重需求”（MD）网络的普遍激活表明其具有支持目标导向行为的核心功能。因此，可以在非人类灵长类动物中预测类似的网络，这些动物在训练后很容易执行类似的任务。然而，非人类灵长类动物的 MD 网络尚未被描述。猕猴额叶和顶叶皮层的单细胞记录显示出一些与人类 MD fMRI 反应相似的特性（例如，任务相关信息的自适应编码）。然而，侵入性记录来自有限的预先指定的位置，因此它们不能描绘出 MD 系统的猕猴同源物，并且它们的定位可以受益于对 MD 病灶所在位置的了解。扫描动物行为的挑战意味着很少有猕猴功能磁共振成像研究专门对比认知需求水平，因此我们试图在 35 只恒河猴中使用功能磁共振成像连接来识别与人类 MD 系统相对应的猕猴。假定的猕猴 MD 区域是根据人类定义的额顶叶 MD 区域绘制的，被发现在麻醉下具有功能连接。为了进一步细化这些区域，使用迭代过程来最大化它们在动物之间交叉验证的连接性。最后，全脑连接分析确定了与 MD 区域牢固连接的体素，揭示了与人类 MD 区域相当的额顶叶和岛叶皮质中的 7 个簇，以及侧裂中的一个意想不到的簇。所提出的猕猴 MD 区域可用于指导未来 MD 神经编码的电生理学研究和基于任务的功能磁共振成像，以测试与人类 MD 皮层类似功能特性的预测。
In humans, cognitively demanding tasks of many types recruitcommonfrontoparietal brain areas. Pervasive activation of this "multiple-demand" (MD) network suggests a core function in supporting goal-oriented behavior. A similar network might therefore be predicted in nonhuman primates that readily perform similar tasks after training. However, an MD network in nonhuman primates has not been described. Single-cell recordings from macaque frontal and parietal cortex show some similar properties to human MD fMRI responses (e.g., adaptive coding of task-relevant information). Invasive recordings, however, come from limited prespecified locations, so they do not delineate a macaque homolog of the MD system and their positioning could benefit from knowledge of where MD foci lie. Challenges of scanning behaving animals mean that few macaque fMRI studies specifically contrast levels of cognitive demand, so we sought to identify a macaque counterpart to the humanMDsystem using fMRI connectivity in 35 rhesus macaques. Putative macaque MD regions, mapped from frontoparietal MD regions defined in humans, were found to be functionally connected under anesthesia. To further refine these regions, an iterative process was used to maximize their connectivity cross-validated across animals. Finally, whole-brain connectivity analyses identified voxels that were robustly connected to MD regions, revealing seven clusters across frontoparietal and insular cortex comparable to human MD regions and one unexpected cluster in the lateral fissure. The proposed macaque MD regions can be used to guide future electrophysiological investigation of MD neural coding and in task-based fMRI to test predictions of similar functional properties to human MD cortex.