Noradrenergic terminal excitability: effects of opioids.
Noradrenergic terminal excitability: effects of opioids.
复制标题
去甲肾上腺素能末端兴奋性：阿片类药物的作用。
DOI：
10.1016/0304-3940(82)90012-x
复制
发表时间：
1982
影响因子：
2.5
通讯作者：
Groves,PM
中科院分区：
文献类型：
--
作者：
Nakamura,S;Tepper,JM;Young,SJ;Ling,N;Groves,PM
The local infusion of morphine ord-Ala2,Met5-enkephalinamide into the frontal cortical terminal fields of noradrenergic neurons of the nucleus locus coeruleus resulted in a decrease in the excitability of the axon terminal regions to direct electrical stimulation. These effects were concentration dependent and could be blocked or partially reversed by the local infusion of naloxone. Some evidence was obtained for a differential antagonizing effect of naloxone upon the effects of morphine andd-Ala2, Met5-enkephalinamide. These results are discussed with respect to an effect of opioids on the polarization and/or ionic conductance of the terminal fields of locus coeruleus neurons, and to the possible regulation of neurotransmitter release by presynaptic opiate receptors.
