Improving pandemic influenza risk assessment.
Improving pandemic influenza risk assessment.
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DOI：
10.7554/elife.03883
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发表时间：
2014-10-16
期刊：
影响因子：
7.7
通讯作者：
Bloom JD
中科院分区：
文献类型：
--
作者：
Russell CA;Kasson PM;Donis RO;Riley S;Dunbar J;Rambaut A;Asher J;Burke S;Davis CT;Garten RJ;Gnanakaran S;Hay SI;Herfst S;Lewis NS;Lloyd-Smith JO;Macken CA;Maurer-Stroh S;Neuhaus E;Parrish CR;Pepin KM;Shepard SS;Smith DL;Suarez DL;Trock SC;Widdowson MA;George DB;Lipsitch M;Bloom JD
Assessing the pandemic risk posed by specific non-human influenza A viruses is an important goal in public health research. As influenza virus genome sequencing becomes cheaper, faster, and more readily available, the ability to predict pandemic potential from sequence data could transform pandemic influenza risk assessment capabilities. However, the complexities of the relationships between virus genotype and phenotype make such predictions extremely difficult. The integration of experimental work, computational tool development, and analysis of evolutionary pathways, together with refinements to influenza surveillance, has the potential to transform our ability to assess the risks posed to humans by non-human influenza viruses and lead to improved pandemic preparedness and response. DOI: http://dx.doi.org/10.7554/eLife.03883.001
