Initial depression and response to imipramine in agoraphobia.
Initial depression and response to imipramine in agoraphobia.
复制标题
广场恐惧症中的初始抑郁和对丙咪嗪的反应。
DOI：
10.1097/00005053-198706000-00006
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发表时间：
1987
期刊：
影响因子：
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通讯作者：
Mavissakalian,M
中科院分区：
文献类型：
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作者：
Mavissakalian,M
参加丙咪嗪对照治疗研究的 37 名患者在两项抑郁指标上同时被分类为高抑郁或低抑郁。 2（高-低抑郁）X 2（高-低丙咪嗪剂量）分组的方差分析显示剂量显着，但没有抑郁主要影响。在低抑郁症组中观察到的较大剂量效应以及在低初始抑郁症的高剂量患者中发现的较高反应率强烈表明，丙咪嗪对广场恐惧症的有益作用本质上并不是主要的抗抑郁作用。
Thirty-seven patients participating in a controlled treatment study with imipramine were classified as high or low depressed simultaneously on two depression measures. Analysis of variance by 2 (high-low depressed) X 2 (high-low imipramine dosage) groupings revealed significant dose but no depression main effects. The greater dose effect observed in the low depressed group and the greater response rates found among high-dose patients with low initial depression strongly suggest that the beneficial effect of imipramine in agoraphobia was not primarily antidepressant in nature.