Ablation of Cancer
Ablation of Cancer
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癌症消融
DOI：
10.1002/adfm.201303345
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发表时间：
2014-04-01
影响因子：
19
通讯作者：
Liu, Zhuang
中科院分区：
文献类型：
--
作者：
Li, Zhiwei;Yin, Shengnan;Liu, Zhuang
纳米医学的蓬勃发展为癌症的诊断和治疗提供了巨大的机遇。在此，开发了使用多功能磁等离子体纳米试剂的磁靶向增强癌症治疗诊断策略，并且实现了基于磁共振（MR）/光声（PA）多模态成像精心规划的高效体内肿瘤光热治疗。通过施加聚焦于靶向肿瘤的外部磁场（MF），观察到磁靶向介导的增强的渗透性和保留（MT-EPR）效应。虽然MR扫描提供肿瘤定位并揭示纳米颗粒的时间依赖性肿瘤归巢用于治疗计划，但具有更高空间分辨率的光声成像允许非侵入性精细肿瘤边缘描绘和肿瘤内治疗诊断纳米颗粒的三维分布的生动可视化。利用这些纳米颗粒的近红外（NIR）等离子体吸收，进行选择性光热肿瘤消融，其疗效通过实时红外热成像在治疗中预测，然后通过MR成像监测治疗后预后。总体而言，本研究阐述了基于多功能纳米制剂的成像引导MF靶向光热治疗的概念，旨在优化治疗计划以实现最有效的癌症治疗。
The booming development of nanomedicine offers great opportunities for cancer diagnostics and therapeutics. Herein, a magnetic targeting-enhanced cancer theranostic strategy using a multifunctional magnetic-plasmonic nano-agent is developed, and a highly effective in vivo tumor photothermal therapy, which is carefully planed based on magnetic resonance (MR)/photoacoustic (PA) multimodal imaging, is realized. By applying an external magnetic field (MF) focused on the targeted tumor, a magnetic targeting mediated enhanced permeability and retention (MT-EPR) effect is observed. While MR scanning provides tumor localization and reveals time-dependent tumor homing of nanoparticles for therapeutic planning, photoacoustic imaging with higher spatial resolution allows noninvasive fine tumor margin delineation and vivid visualization of three dimensional distributions of theranostic nanoparticles inside the tumor. Utilizing the near-infrared (NIR) plasmonic absorbance of those nanoparticles, selective photothermal tumor ablation, whose efficacy is predicted by real-time infrared thermal imaging intra-therapeutically, is carried out and then monitored by MR imaging for post-treatment prognosis. Overall, this study illustrates the concept of imaging-guided MF-targeted photothermal therapy based on a multifunctional nano-agent, aiming at optimizing therapeutic planning to achieve the most efficient cancer therapy.