Visceral Adiposity Index: a reliable indicator of visceral fat function associated with cardiometabolic risk.
Visceral Adiposity Index: a reliable indicator of visceral fat function associated with cardiometabolic risk.
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DOI：
10.2337/dc09-1825
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发表时间：
2010-04
期刊：
影响因子：
16.2
通讯作者：
AlkaMeSy Study Group
中科院分区：
文献类型：
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作者：
Amato MC;Giordano C;Galia M;Criscimanna A;Vitabile S;Midiri M;Galluzzo A;AlkaMeSy Study Group
个体化一种新的性别特异性指数，基于腰围，BMI，甘油三酯和HDL胆固醇，间接表达内脏脂肪功能。内脏肥胖指数（VAI）首先在315名非肥胖健康受试者中建模。使用两个多元逻辑回归模型，VAI在1,498例初级保健患者中进行了回顾性验证，并与经典的心脑血管危险因素进行了比较。在VAI五分位数中，代谢综合征的所有组分均显著增加。VAI与心血管事件（比值比[OR] 2.45; 95%CI 1.52-3.95; P < 0.001）和脑血管事件（1.63; 1.06-2.50; P = 0.025）独立相关。在一个亚组的患者中，VAI与正常血糖-高胰岛素钳夹过程中的胰岛素敏感性呈显著负相关（Rs =-0.721; P < 0.001）。相比之下，腰围和BMI没有相关性。我们的研究表明，VAI是“内脏脂肪功能”和胰岛素敏感性的一个有价值的指标，其增加与心脏代谢风险密切相关。
To individuate a novel sex-specific index, based on waist circumference, BMI, triglycerides, and HDL cholesterol, indirectly expressing visceral fat function. Visceral adiposity index (VAI) was first modeled on 315 nonobese healthy subjects. Using two multiple logistic regression models, VAI was retrospectively validated in 1,498 primary care patients in comparison to classical cardio- and cerebrovascular risk factors. All components of metabolic syndrome increased significantly across VAI quintiles. VAI was independently associated with both cardiovascular (odd ratio [OR] 2.45; 95% CI 1.52–3.95; P < 0.001) and cerebrovascular (1.63; 1.06–2.50; P = 0.025) events. VAI also showed significant inverse correlation with insulin sensitivity during euglycemic-hyperinsulinemic clamp in a subgroup of patients (Rs = −0.721; P < 0.001). By contrast, no correlations were found for waist circumference and BMI. Our study suggests VAI is a valuable indicator of “visceral adipose function” and insulin sensitivity, and its increase is strongly associated with cardiometabolic risk.