Post-radiation sarcomas: A review of the clinical and imaging features in 63 cases
Post-radiation sarcomas: A review of the clinical and imaging features in 63 cases
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DOI：
10.1053/crad.2000.0599
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发表时间：
2001-01-01
影响因子：
2.6
通讯作者：
Libshitz, HI
中科院分区：
文献类型：
--
作者：
Sheppard, DG;Libshitz, HI
目标：肉瘤的发展是公认的放射治疗的并发症，我们开始回顾性审查的临床和治疗人口统计学，以及放射后肉瘤患者的横断面影像学表现，材料和方法：63例放射后肉瘤患者在一个单一的机构确定，计算机断层扫描和/或磁共振成像可用于所有患者。结果：本组病例中，女性43例，男性20例，平均年龄52.8岁。平均辐射剂量为50.1 GS，肉瘤发生的平均潜伏期为15.5年。最常见的原发性诊断为乳腺癌、淋巴瘤和头颈部癌。最常见的肉瘤组织病理学是骨肉瘤和恶性纤维组织细胞瘤，最常见的影像学表现是软组织肿块和骨破坏。结论：放射后肉瘤，虽然不常见，并不罕见。影像学所见并非特异性表现，但对预期潜伏期的评估可能有助于诊断。Sheppard，D. G.和Libshitz，H. I.（2001年）的第10页。临床放射学56，22-29，（C）2001年，皇家放射医师学院。
AIMS: The development of sarcomas is a recognized complication of radiation therapy, We set out to retrospectively review the clinical and therapeutic demographics, as well as the cross-sectional imaging findings in patients with post-radiation sarcomas,MATERIALS AND METHODS: Sixty-three patients with post-radiation sarcomas were identified at a single institution, Computed tomography and/or magnetic resonance imaging was available for all patients. The medical records were reviewed for the primary diagnoses, the radiation history, and the latency period to the development of the sarcoma.RESULTS: There were 43 women and 20 men with a mean age of 52.8 years. The mean radiation dose delivered was 50.1 GS, with a mean latency period for the development of the sarcoma of 15.5 years, The most common primary diagnoses were breast cancer, lymphoma and head and neck cancer. The most common sarcoma histopathologies were osteosarcoma and malignant fibrous histiocytoma, The most common imaging findings were a soft tissue mass and bone destruction.CONCLUSIONS: Post-radiation sarcomas, while uncommon, are not rare. The imaging findings are not pathognomonic, but an appreciation of the expected latency period may help to suggest the diagnosis. Sheppard, D. G. and Libshitz, H. I. (2001). Clinical Radiology 56, 22-29, (C) 2001 The Royal College of Radiologists.