Complete genomic sequences of astroviruses from sheep and turkey: comparison with related viruses
Complete genomic sequences of astroviruses from sheep and turkey: comparison with related viruses
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DOI：
10.1016/s0168-1702(02)00269-1
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发表时间：
2003-02-01
期刊：
影响因子：
5
通讯作者：
Grinde, B
中科院分区：
文献类型：
--
作者：
Jonassen, CM;Jonassen, TO;Grinde, B
对感染绵羊和火鸡的星状病毒的基因组进行了测序。对这些序列进行了详细分析，包括与其他完整的星状病毒序列以及其他RNA病毒序列进行比较，重点是非结构蛋白和RNA序列。早期假定的功能性星状病毒RNA基序和蛋白质结构域在大多数情况下可以在绵羊和火鸡星状病毒序列中识别。此外，可用的星状病毒序列的分析显示：两个蛋白质区域与潜在的形成卷曲螺旋，在假定的跨膜区的差异，推定的星状病毒核定位信号和杯状病毒基因组连接的蛋白质之间的相似性，和一个高度保守的RNA序列的伸展与星状病毒衣壳基因表达的可能作用。目前的分析有助于破译相关功能的星状病毒基因组。(C)2002 Elsevier Science B.V.保留所有权利。
The genomes of astroviruses infecting sheep and turkey were sequenced. Detailed analyses of these sequences were performed, including comparison with the other complete astrovirus sequences available as well as with other RNA virus sequences, with focus on the non-structural proteins and RNA sequences. Earlier postulated functional astrovirus RNA motifs and protein domains could in most cases be recognised in the sheep and turkey astrovirus sequences. In addition, analyses of the available astrovirus sequences revealed: two protein regions with the potential for forming coiled coils, differences in the postulated transmembrane region, a similarity between the putative astrovirus nuclear localisation signal and calicivirus genome-linked proteins, and a stretch of a highly conserved RNA sequence with a possible role in the astrovirus capsid gene expression. The present analyses contribute to the deciphering of pertinent functions of the astrovirus genomes. (C) 2002 Elsevier Science B.V. All rights reserved.