Odor perception phenotypes: Multiple, specific hyperosmias to musks
Odor perception phenotypes: Multiple, specific hyperosmias to musks
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DOI：
10.1093/chemse/21.4.411
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发表时间：
1996-08-01
期刊：
影响因子：
3.5
通讯作者：
Kemp, SE
中科院分区：
文献类型：
--
作者：
Gilbert, AN;Kemp, SE
从32名受试者中获得了11种结构不同的麝香气味剂和1种非麝香气味剂的嗅觉检测阈值。分层聚类分析产生了四组受试者。一组（n = 12）对所有麝香均敏感；另一个（n = 16）完全不敏感。两组受试者中包含对环戊烷酮和麝香二甲苯（n = 2）以及对delta9-十六烯内酯和tonalid （n = 2）异常敏感的不敏感个体。我们认为后两组是气味感知表型（MSHM1和MSHM2），由对麝香气味的多种特异性高嗅觉组成。
Olfactory detection thresholds for 11 structurally diverse musk odorants and one non-musk odorant were obtained from 32 subjects. Hierarchical cluster analysis produced four groups of subjects. One group (n = 12) was uniformly sensitive to all musks; another (n = 16) was uniformly insensitive. Two groups of subjects contained otherwise insensitive individuals who were exceptionally sensitive to cyclopentadecanone and musk xylol (n = 2) and to delta9-hexadecenolactone and tonalid (n = 2) respectively. We propose that the latter two groups are odor perception phenotypes (MSHM1 and MSHM2) that consist of multiple, specific hyperosmias to musk odorants.