Evolution of plus disease in retinopathy of prematurity: quantification by ROPtool.
Evolution of plus disease in retinopathy of prematurity: quantification by ROPtool.
复制标题
早产儿视网膜病变中正号疾病的演变：通过 ROPtool 进行量化。
DOI：
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发表时间：
2009
期刊：
影响因子：
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通讯作者：
Zheen Zhao
中科院分区：
文献类型：
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作者：
D. Wallace;S. Freedman;Zheen Zhao
目的
激光治疗早产儿视网膜病变 (ROP) 的主要适应症是附加疾病，或小动脉和小静脉的异常扩张和扭曲。 ROPtool 是一种计算机程序，可追踪视网膜血管并测量其宽度和弯曲度。我们的目的是通过将 ROPtool 应用到婴儿眼睛的 RetCam 图像（在 ROP 筛查期间拍摄了一系列照片）来深入了解正畸疾病的演变。
方法
作为另一项研究的一部分，我们收集了 62 名接受 ROP 筛查的婴儿眼睛的系列图像。 ROPtool 选择并分析了 7 名患有疾病的婴儿一只眼睛的 59 张图像。对于每个图像计算每个象限中最弯曲血管的平均弯曲度和最扩张血管的平均宽度。
结果
弯曲度从第一次检查时的平均 7.72 个单位增加到最大弯曲度检查时的 24.44 个单位，即在 6.2 周的平均时间段内增加了 217%。与第一次检查相比，两只眼睛的弯曲度增加了 500% 以上。血管宽度从第一次检查时的平均 8.60 个单位增加到最大血管宽度检查时的 11.03 个单位，即在 5.1 周的平均时间段内增加了 28%。
结论
ROPtool 可以测量个体眼睛视网膜血管扩张和扭曲度随时间的变化。随着疾病的发展，弯曲度的变化有时非常大，而血管宽度的变化往往更微妙。随着时间的推移对+疾病进行量化可能有助于提高我们对其机制的理解并监测疾病进展或对治疗的反应。
PURPOSE
The primary indication for laser treatment in retinopathy of prematurity (ROP) is plus disease, or abnormal dilation and tortuosity of arterioles and venules. ROPtool is a computer program that traces retinal blood vessels and measures their width and tortuosity. Our purpose was to gain insight into the evolution of plus disease by applying ROPtool to RetCam images from eyes of infants who had serial photographs taken during their ROP screening period.
METHODS
Serial images were collected from eyes of 62 infants screened for ROP as part of another study. Fifty-nine images of one eye of 7 infants who developed plus disease were selected and analyzed by ROPtool. The average tortuosity of the most tortuous blood vessel and the average width of the most dilated vessel in each quadrant were calculated for each image.
RESULTS
Tortuosity increased from an average of 7.72 units at the first examination to 24.44 units at the examination with maximum tortuosity, or an increase of 217% over a mean time period of 6.2 weeks. Two eyes had an increase in tortuosity of more than 500% from the first examination. Vessel width increased from an average of 8.60 units at the first examination to 11.03 units at the examination with maximum blood vessel width, or an increase of 28% over a mean time period of 5.1 weeks.
CONCLUSIONS
ROPtool can measure changes in retinal vascular dilation and tortuosity in individual eyes over time. As plus disease develops, changes in tortuosity are sometimes very large, whereas changes in vessel width tend to be more subtle. Quantification of plus disease over time may help to improve our understanding of its mechanism and to monitor disease progression or response to treatment.
影响因子：
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作者：
W. Tasman
通讯作者：
W. Tasman
冷冻疗法治疗早产儿视网膜病变的多中心试验。
DOI：
10.1001/archopht.1988.01060130517027
发表时间：
1988
期刊：
Archives of ophthalmology (Chicago, Ill. : 1960)
影响因子：
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作者：
通讯作者：
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