Evidence relating human verbal memory to hippocampal N-methyl-D-aspartate receptors
Evidence relating human verbal memory to hippocampal N-methyl-D-aspartate receptors
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DOI：
10.1073/pnas.96.21.12085
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发表时间：
1999-10-12
影响因子：
11.1
通讯作者：
Elger, CE
中科院分区：
文献类型：
--
作者：
Grunwald, T;Beck, H;Elger, CE
对啮齿动物和非人类灵长类动物的研究表明，海马体内n -甲基- d -天冬氨酸（NMDA）受体的活性与动物在记忆相关任务中的表现有关。然而，这些受体是否对人类记忆同样重要仍然是一个悬而未决的问题。在这里，我们提出的证据表明，海马NMDA受体，最有可能在CA1区域内，确实参与了人类的言语记忆过程。单词在前内侧颞叶（AMTL-N400）内引起负事件相关电位（ERP）在400 ms左右达到峰值。氯胺酮，一种nmda受体拮抗剂，在初次出现时降低AMTL-N400的振幅（与其他海马电位相比），消除了典型的AMTL-N400振幅减少，并导致显著的记忆障碍。在不同的海马体亚区中，只有CA1神经元的密度与氯胺酮减少的单词相关的erp相关。总之，我们的行为、解剖和电生理结果表明，海马NMDA受体与人类记忆有关。
Studies in rodents and nonhuman primates have linked the activity of N-methyl-D-aspartate (NMDA) receptors within the hippocampus to animals' performance on memory-related tasks. However, whether these receptors are similarly essential for human memory is still an open question. Here we present evidence suggesting that hippocampal NMDA receptors, most likely within the CA1 region, do participate in human verbal memory processes. Words elicit a negative event-related potential (ERP) peaking around 400 ms within the anterior mesial temporal lobe (AMTL-N400). Ketamine, an NMDA-receptor antagonist, reduces the amplitude of the AMTL-N400 (in contrast to other hippocampal potentials) on initial presentation, eliminates the typical AMTL-N400 amplitude reduction with repetition, and leads to significant memory impairment. Of the various hippocampal subfields, only the density of CA1 neurons correlates with the word-related ERPs that are reduced by ketamine. Altogether, our behavioral, anatomical, and electrophysiological results indicate that hippocampal NMDA receptors are involved in human memory.