Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice
Capsaicin provokes apoptosis and restricts benzo(a)pyrene induced lung tumorigenesis in Swiss albino mice
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DOI：
10.1016/j.intimp.2013.05.015
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发表时间：
2013-10-01
影响因子：
5.6
通讯作者：
Devaki, T.
中科院分区：
文献类型：
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作者：
Anandakumar, P.;Kamaraj, S.;Devaki, T.
辣椒素（Capsaicin，CAP）是红辣椒和红辣椒中的一种成分，具有显著的抗癌作用.本研究通过检测细胞凋亡标志物，探讨CAP对苯并（a）芘诱导的小鼠肺肿瘤的抗肿瘤作用。CAP（10 mg/kg体重）腹腔注射给瑞士白化病小鼠抑制肺癌的发展，通过修改凋亡调节蛋白p53，Bcl-2，Bax和caspase-3的蛋白表达。DNA琼脂糖凝胶电泳、透射电镜观察和溴化乙锭/吖啶橙子染色进一步证实了CAP的致瘤作用。本研究结果表明CAP通过诱导细胞凋亡抑制小鼠肺癌的发生。我们的研究结果为CAP作为一种抗癌化合物对肺癌的进一步临床研究提供了基础。(C)2013爱思唯尔有限公司版权所有。
Capsaicin (CAP), a constituent of red chilli and red pepper is exposed to exert compelling anticarcinogenic effects. In the present study, we examined the anti-tumorigenic potential of CAP on benzo(a)pyrene-induced mice lung tumorigenesis by analyzing the markers of apoptosis. Intraperitoneal administration of CAP (10 mg/kg body weight) to Swiss albino mice suppressed the development of lung carcinoma by amending the protein expressions of apoptotic regulators p53, Bcl-2, Bax and caspase-3. The apoptotic-inducing nature of CAP was further confirmed by DNA agarose gel electrophoresis, transmission electron microscopic study and ethidium bromide/acridine orange staining. The results obtained from the present study show that CAP inhibits the development of mice lung carcinogenesis through its ability to induce apoptosis. Our present findings provide the basis for further clinical exploration of CAP as an anti-carcinogenic compound against lung carcinogenesis. (C) 2013 Elsevier B.V. All rights reserved.