Antiribosomal P antibodies in pediatric patients with systemic lupus erythematosus and psychosis
Antiribosomal P antibodies in pediatric patients with systemic lupus erythematosus and psychosis
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DOI：
10.1002/art.1780390420
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发表时间：
1996-04-01
影响因子：
--
通讯作者：
Silverman, ED
中科院分区：
文献类型：
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作者：
Press, J;Palayew, K;Silverman, ED
Objective.研究系统性红斑狼疮（SLE）患儿抗核糖体P蛋白抗体的变化，该蛋白是SLE抑郁和精神病的敏感和特异性标志物。收集79例SLE患者的血清标本106份。采用酶联免疫吸附试验（ELISA）检测60份年龄、性别匹配的正常对照血清和12份原发性精神病患儿血清中的重组核糖体P（rRP）抗体。12例非SLE相关精神病患儿抗rRP抗体均正常，64例无精神病史的SLE患儿中11例（17%）抗rRP抗体升高，13例SLE伴精神病患儿中5例（38%）抗rRP抗体在精神病急性期升高，缓解期明显下降，此外，大多数无精神病史的SLE患者抗rRP抗体水平与疾病活动性有良好的相关性，有精神病史的SLE患者肾脏受累明显少于无精神病史的SLE患者，这种明显的肾脏保护作用与抗核糖体P或抗DNA抗体的存在与否无关。血清核糖体P蛋白抗体水平升高可区分SLE相关精神病和儿童原发性精神病。在SLE中，抗核糖体P抗体水平升高对精神病无特异性。系列测定可用于监测疾病活动。
Objective. To study antibodies directed against ribosomal P proteins, a sensitive and specific marker of depression and psychosis in systemic lupus erythematosus (SLE), in pediatric patients with SLE.Methods. One hundred six serum samples were obtained from 79 patients with SLE. Sixty age- and sex-matched control sera were obtained, and 12 samples were obtained from children with primary psychosis, Antibodies to recombinant ribosomal P (rRP) protein were detected using a standard enzyme-linked immunosorbent assay.Results. All 12 children with non-SLE-associated psychosis had normal levels of anti-rRP antibodies, Elevated levels of anti-rRP were found in 11 of 64 pediatric SLE patients without a history of psychosis (17%), In the group of 13 SLE patients with psychosis, 5 (38%) had increased anti-rRP antibody levels during the time of acute psychosis, and which significantly decreased during remission, In addition, most of the SLE patients without a history of psychosis had a good correlation between anti-rRP antibody levels and disease activity, The patients with psychosis had significantly less renal involvement than the patients without a history of psychosis, This apparent protection from renal disease was not related to the presence or absence of either antiribosomal P or anti-DNA antibodies.Conclusion. Elevated serum levels of antibodies to ribosomal P protein can distinguish SLE-associated psychosis from primary psychosis of childhood, In SLE, elevated antiribosomal P antibody levels were not specific for psychosis. Serial assays were useful for monitoring the disease activity.