EARLY INGROWTH OF THALAMOCORTICAL AFFERENTS TO THE NEOCORTEX OF THE PRENATAL RAT
EARLY INGROWTH OF THALAMOCORTICAL AFFERENTS TO THE NEOCORTEX OF THE PRENATAL RAT
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DOI：
10.1073/pnas.88.8.2999
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发表时间：
1991-04-01
影响因子：
11.1
通讯作者：
KILLACKEY, HP
中科院分区：
文献类型：
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作者：
CATALANO, SM;ROBERTSON, RT;KILLACKEY, HP
在胎鼠中检查了丘脑皮质传入纤维进入假定的躯体感觉皮质的初始向内生长。 用碳菁染料1，1 ′-双十八烷基-3，3，3 ′，3 ′-四甲基吲哚碳菁高氯酸盐（DiI）标记固定脑中的丘脑纤维。 在胚胎第16天，丘脑皮质传入神经到达新皮质，并在皮质板下方的中间区内切向传播。 到胚胎第17天，丘脑皮质纤维已经开始向皮质放射状生长，它们的主干跨越VIb层和皮质板底部之间的细胞稀疏区。 出生当天（胚胎第21天），丘脑皮质纤维在致密皮质板下方的第VI层和第V层内形成致密的神经丛。 我们的观察结果表明，在大鼠丘脑传入到达皮层在一个非常早期的年龄和树枝状内形成皮层层没有一个明显的“等待”期。
The initial ingrowth of thalamocortical afferents into the presumptive somatosensory cortex was examined in the fetal rat. Thalamic fibers were labeled in fixed brains with the carbocyanine dye 1,1'-dioctadecyl-3,3,3',3'-tetramethylindocarbocyanine perchlorate (DiI). On embryonic day 16, thalamocortical afferents arrive in the neocortex and course tangentially within the intermediate zone immediately underneath the cortical plate. By embryonic day 17, thalamocortical fibers have begun their radial growth into cortex and their arbors span the cell-sparse zone between layer VIb and the bottom of the cortical plate. By the day of birth (embryonic day 21), thalamocortical fibers form a dense plexus within layers VI and V below the dense cortical plate. Our observations indicate that in the rat thalamic afferents arrive in the cortex at a very early age and arborize within the forming cortical layers without an apparent "waiting" period.