Biologic clocks and the gut.
Biologic clocks and the gut.
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DOI：
10.1007/s11894-006-0019-3
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发表时间：
2006-10-01
影响因子：
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通讯作者：
Hoogerwerf, Willemijntje A
中科院分区：
文献类型：
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作者：
Hoogerwerf, Willemijntje A
胃肠道在基础胃酸排出、上皮细胞增殖、胃肠动力和食欲调节方面显示生物节律。此外，阿司匹林给药后以及转移性结肠癌化疗和放疗后胃肠道并发症的发生取决于给药时间。生物节律由所谓的时钟基因驱动。因此，可以想象，胃肠道中的基因子集也受到时钟基因的控制。本文的目的是讨论生物节律研究中的基本概念，回顾胃肠道生物节律的例子，并讨论生物节律改变可能起致病作用的胃肠道疾病的例子。
The gastrointestinal tract displays biologic rhythms in basal gastric acid output, epithelial cell proliferation, gastrointestinal motility, and appetite regulation. Furthermore, the development of gastrointestinal complications after administration of aspirin and after chemo- and radiotherapy for metastatic colon cancer depends on the time of administration. Biologic rhythms are driven by so-called clock genes. Thus, it is conceivable that subsets of genes in the gastrointestinal tract are under clock gene control as well. The purpose of this article is to discuss basic concepts in the studies of biologic rhythms, to review examples of biologic rhythms in the gastrointestinal tract, and to discuss examples of gastrointestinal diseases in which alterations in biologic rhythms may play a pathogenetic role.